RecruitingNCT04449523

Incidence of Silent Atrial Fibrillation in Patients With Clinically Silent Brain Ischemic Lesions

Incidence of Silent Atrial Fibrillation in Patients With Clinically Silent Brain Ischemic Lesions (SILENT2)


Sponsor

Insel Gruppe AG, University Hospital Bern

Enrollment

150 participants

Start Date

Sep 8, 2020

Study Type

OBSERVATIONAL

Conditions

Summary

Arterial Fibrillation (AF) is well-recognized as a cause for cryptogenic Acute Ischemic Stroke (AIS) and is associated with Silent Brain Infarction (SBI). However, the role of AF in the formation of lesions (SBIs) is less well established than its role in AIS and needs clarification. The investigators hypothesize that continuous rhythm monitoring will yield a similar incidence of AF diagnosis in patients with SBI as compared to patients with cryptogenic AIS. The primary objective is to assess the cumulative incidence of AF diagnosis at 24 months in patients with SBI.


Eligibility

Min Age: 50 Years

Plain Language Summary

Simplified for easier understanding

This study is monitoring older adults who have had silent (symptom-free) strokes on brain scans to see how often they develop undetected atrial fibrillation (an irregular heart rhythm that increases stroke risk). **You may be eligible if...** - You are 65 or older, OR 50 or older with specific heart risk factors (elevated NT-proBNP blood level or an enlarged left atrium) - A brain MRI or CT scan has shown small silent strokes or white matter changes - You have no prior history of atrial fibrillation **You may NOT be eligible if...** - You have a known history of atrial fibrillation or atrial flutter - You have had symptoms of a stroke (only silent brain findings are eligible) - You already have a pacemaker or implanted heart rhythm device - You are already on anticoagulants (blood thinners) for other reasons Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Locations(8)

Universitätsspital Graz

Graz, Austria

Charite Berlin

Berlin, Germany

Centre hospitalier universitaire vaudois (CHUV)

Lausanne, Canton of Vaud, Switzerland

Kantonsspital Aarau

Aarau, Switzerland

University Hospital Basel

Basel, Switzerland

Inselspital Bern

Bern, Switzerland

Kantonsspital St.Gallen

Sankt Gallen, Switzerland

Universitätsspital Zurich

Zurich, Switzerland

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NCT04449523


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