Phase IIa Trial of a Selective Glucocorticoid Receptor Antagonist in the Treatment of Veterans With Posttraumatic Stress Disorder (PTSD) (Seven Study)

This study is testing a new medication that blocks a specific stress hormone receptor in the brain to see if it can reduce PTSD symptoms in military veterans. Standard PTSD treatments don't work for everyone, so researchers are looking for new options. **You may be eligible if:** - You are a US military veteran with PTSD symptoms - You can read and understand English - If you take antidepressants (SSRIs or SNRIs) for PTSD, you have been on a stable dose for at least 8 weeks - If you are in therapy, your treatment has been stable for at least 6 weeks **You may NOT be eligible if:** - You have had alcohol use disorder, drug use disorder, or a substance use disorder in the past 3 months - You have been diagnosed with bipolar disorder, schizophrenia, or psychotic depression - You experienced a traumatic event in the last 3 months - You currently take antipsychotics, lithium, or certain older antidepressants - You have untreated sleep apnea - You currently use steroids (oral or inhaled) - You have significant heart, kidney, or liver problems - You have uncontrolled high blood pressure or diabetes Talk to your doctor to see if this trial is right for you.