RecruitingNCT04460859

RecruitmEnt Assessed by eleCtRical Impedance Tomography

RecruitmEnt Assessed by eleCtRical Impedance Tomography: Feasibility, Correlation With Clinical oUtcomes and pIloT Data on Personalised PEEP Selection.

Sponsor

Unity Health Toronto

Enrollment

171 participants

Start Date

Jun 9, 2020

Study Type

OBSERVATIONAL

Conditions

Acute Respiratory Distress Syndrome (ARDS)

Summary

The RECRUIT study is a multinational, multicenter physiological observational study conducted by the PLUG working group. It is a single-day study (1.5-2 hours) associated with specific lung (de)recruitment maneuvers to verify the feasibility of measuring the potential for lung recruitment in mechanically ventilated patients with ARDS by electrical impedance tomography (EIT).

Eligibility

Min Age: 18 Years

Inclusion Criteria2

Intubated moderate and severe ARDS according to the Berlin definition (PaO2/FiO2 ratio <= 200 mmHg)
Under continuous sedation with or without paralysis

Exclusion Criteria6

Age <18 years
Bronchopleural fistula
Pure COPD exacerbation
Contraindication to EIT monitoring (e.g. burns, pacemaker, thoracic wounds limiting electrode belt placement)
Hemodynamic instability (Systolic BP < 75 mmHg or MAP < 60 mmHg despite vasopressors and/or heart rate < 55 bpm)
Attending physician deems the transient application of high airway pressures to be unsafe

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Interventions

OTHERSpecific lung recruitment maneuvers

Specific lung recruitment maneuvers will be performed to measure the potential for lung recruitment at different levels of positive end-expiratory pressure (PEEP) provided by the mechanical ventilator. Electrical impedance tomography signals, synchronized signals of airway pressure and flow, esophageal pressure (if available), and volumetric capnography (if available) will be recorded continuously, during the time span of the protocol for offline analysis.