RecruitingNot ApplicableNCT04461301

Multimodal Prehabilitation for Surgery in the Elderly: a Randomised, Prospective, Multicenter, Multidisciplinary Trial

Multimodal Prehabilitation for Major Surgery in Elderly Patients to Lower Complications and to Increase Cost Effectiveness: a Randomised, Prospective, Multicenter, Multidisciplinary Trial (PREHABIL Trial).


Sponsor

Insel Gruppe AG, University Hospital Bern

Enrollment

466 participants

Start Date

Feb 1, 2022

Study Type

INTERVENTIONAL

Conditions

Summary

This multicentric, randomised controlled trial is to the investigators knowledge the first implementation of a multimodal, multidisciplinary prehabilitation approach using knowledge from different specialties to lower complications and to increase cost effectiveness after major surgery in elderly, frail patients.


Eligibility

Min Age: 65 Years

Inclusion Criteria5

  • Written informed consent
  • comorbid (≥ASA 3)
  • pre-existing fitness deficit: AT\<11ml/kg/min respectively VO2peak\<14ml/kg/min if AT unavailable or VE/VCO2 slope \> 33
  • scheduled for major urologic, thoracic, visceral, orthopaedic or cardiovascular surgery
  • screening at least 2 weeks prior to surgery

Exclusion Criteria5

  • Paralysis or patients with mobility problems (who are unable to exercise),
  • Premorbid conditions or orthopaedic impairments that contraindicate exercise,
  • Cognitive disabilities,
  • Chronic renal failure (need for dialysis)
  • Emergency procedures.

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Interventions

PROCEDUREMultimodal Prehabilitation

A multimodal prehabilitation program (exercise, nutrition, anemia correction and smoking cessation).


Locations(1)

Department of Anaesthesiology and Pain Therapy, University Hospital Bern Inselspital Bern

Bern, Canton of Bern, Switzerland

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NCT04461301


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