Major Surgery Clinical Trials

12 recruitingLast updated: May 13, 2026

There are 12 actively recruiting major surgery clinical trials across 11 countries. Studies span Not Applicable, Phase 4. Top locations include Bern, Switzerland, Boulogne-Billancourt, France, Cagliari, Sardinia, Italy. Updated daily from ClinicalTrials.gov.


Major Surgery Trials at a Glance

12 actively recruiting trials for major surgery are listed on ClinicalTrialsFinder across 6 cities in 11 countries. The largest study group is Not Applicable with 4 trials, with the heaviest enrollment activity in Bern, Boulogne-Billancourt, and Cagliari. Lead sponsors running major surgery studies include Assistance Publique - Hôpitaux de Paris, Insel Gruppe AG, University Hospital Bern, and Adichunchanagiri Institute of Medical Sciences, B G Nagara.

Browse major surgery trials by phase

Treatments under study

About Major Surgery Clinical Trials

Looking for clinical trials for Major Surgery? There are currently 5 studies actively recruiting participants. Clinical trials offer access to new treatments before they are widely available, and every approved therapy in use today was first tested through a clinical trial.

Below you can browse trials, sign up for alerts when new Major Surgery trials open, and view eligibility criteria for each study. Each listing includes the study phase, locations, and enrollment details.

Frequently Asked Questions

Common questions about Major Surgery clinical trials

A clinical trial is a carefully designed research study that tests new medical treatments, drugs, devices, or approaches in human volunteers. Every approved medication and treatment available today was proven safe and effective through clinical trials.

All clinical trials are reviewed and approved by Institutional Review Boards (IRBs) — independent committees that evaluate patient safety. Trials follow strict protocols, and your health is monitored closely throughout. You can withdraw at any time.

Not necessarily. Many trials compare the new treatment against the current standard of care, meaning all participants receive active treatment. When placebos are used, they are typically combined with standard treatment, not given alone. The trial description will always specify the design.

Under the Affordable Care Act, most private insurers are required to cover routine patient care costs during a clinical trial. The sponsor typically covers the investigational treatment itself. Medicare also covers routine costs for qualifying trials.

Yes. Participation is completely voluntary. You can withdraw at any time, for any reason, without it affecting your access to standard medical care.

Each trial has specific eligibility criteria — including age, diagnosis, disease stage, prior treatments, and general health. Browse the trials listed above and check their eligibility sections. You can also contact the trial site directly to discuss your situation.

Showing 112 of 12 trials

Recruiting
Phase 4

LANdiolol to Avoid TAchycardia in Patients at Risk for Cardiovascular Events Undergoing Major Non-cardiac Surgery

myocardial injury after non-cardiac surgeryAutonomic DysfunctionCardiovascular (CV) Risk+3 more
Insel Gruppe AG, University Hospital Bern114 enrolled1 locationNCT07168421
Recruiting
Phase 4

PeRiOperative Medicine Platform Trial

Quality of LifeAnaesthesiaSurgical Site Infection After Major Surgery+2 more
Monash University7,800 enrolled2 locationsNCT07186634
Recruiting

The Role of Neuroinflammation on Neurocognitive Outcome in Cardiac Surgery

Postoperative Neurocognitive DisorderQuality of recoveryElderly Patients+5 more
Ziekenhuis Oost-Limburg80 enrolled1 locationNCT07200726
Recruiting

IMMUNOREA - Immunological and Inflammatory Determinants Associated With the Prognosis of Intensive Care Patients

Intensive care patientsCritical IllnessCritical Illness Requiring Intensive Care - Sepsis+3 more
Assistance Publique - Hôpitaux de Paris540 enrolled1 locationNCT07345169
Recruiting
Not Applicable

SurgiPerito Trial: High-Purity Type-I Collagen for Peritoneal Reconstruction After Cytoreductive Surgery

Peritoneal Surface MalignancyPostoperative AdhesionBowel Obstruction+3 more
Adichunchanagiri Institute of Medical Sciences, B G Nagara60 enrolled2 locationsNCT07241091
Recruiting

Morbidity and Mortality: Surgery and Standardized Transmission in Operating Room

Major Surgery
Assistance Publique - Hôpitaux de Paris1,120 enrolled1 locationNCT05440331
Recruiting
Not Applicable

Prehabilitation in Oncological Patients Undergoing Major Gastrointestinal Surgery (PROGRESS)

Major SurgeryOncological Patients
Università Vita-Salute San Raffaele400 enrolled2 locationsNCT06404489
Recruiting
Not Applicable

Effect of High Dose Insulin on Infectious Complications Following Major Surgery

Surgical Site Infection After Major Surgery
McGill University Health Centre/Research Institute of the McGill University Health Centre460 enrolled3 locationsNCT01528189
Recruiting
Phase 4

Analgesic Efficacy of Intravenous Ketamine as a Continuous Infusion vs PCA in the Management of Acute Postoperative Pain in Major Orthopedic Surgery.

Opioid UsePain, PostoperativeMajor Surgery
Universidad de Antioquia120 enrolled1 locationNCT06774274
Recruiting
Not Applicable

Multimodal Prehabilitation for Surgery in the Elderly: a Randomised, Prospective, Multicenter, Multidisciplinary Trial

Frail Elderly SyndromeMajor Surgery
Insel Gruppe AG, University Hospital Bern466 enrolled1 locationNCT04461301
Recruiting

Does measuring pre-surgery brain oxygen levels in sick elderly patients coming in for major elective non-cardiac surgery allow us to predict who will have more complications, including death, major organ failure, and post-operative delirium

outcomes after major surgery
Liverpool Hospital400 enrolled2 locationsACTRN12616000873426
Recruiting
Phase 4

The effects of Sterofundin versus Ringer's Lactate on Acid-base balance and electrolyte status in paediatric patients undergoing major urogenital surgery.

2. to determine any significant differences in electrolyte balance and haemodynamic stability in paediatric patients undergoing major surgery.1. to determine any significant differences in acid base balance in paediatric patients undergoing major surgery .
university malaya50 enrolled1 locationACTRN12612000107820