RecruitingNCT04467944

Effect of Pre-existing Adjacent Segment Degeneration on Long-term Effectiveness After Lumbar Fusion Surgery

Effect of Pre-existing Adjacent Segment Degeneration on Long-term Effectiveness After Lumbar Fusion Surgery: a Prospective Cohort Study


Sponsor

Peking University Third Hospital

Enrollment

210 participants

Start Date

Jan 1, 2018

Study Type

OBSERVATIONAL

Conditions

Summary

This is a prospective single-center study. Patients requiring posterior lumbar interbody fusion (PLIF) for lumbar degenerative disease are prospectively enrolled and followed. Important adjacent pre-existing degeneration factors include discs degenerated, facets and ligamentum flavum tropism which could lead to spinal canal stenosis (SCS). This study will focus on the effects of pre- existing adjacent degeneration (disc factors and spinal canal stenosis factors) on long-term postoperative outcomes.


Eligibility

Min Age: 18 YearsMax Age: 80 Years

Plain Language Summary

Simplified for easier understanding

This study looks at how pre-existing degeneration of the spinal segments adjacent to a lumbar fusion surgery affects long-term outcomes. When a surgeon fuses vertebrae in the lower back (lumbar spine), the discs and joints next to the fusion can sometimes wear out faster — a phenomenon called adjacent segment disease. This study evaluates whether the condition of those neighboring segments before surgery predicts problems years later. You may be eligible if... - You have a confirmed diagnosis of lumbar spinal stenosis requiring surgery at the L4-S1 level - You have tried conservative treatment (physical therapy, injections, etc.) for at least 8 weeks without relief You may NOT be eligible if... - You have instability (slippage, rotation, abnormal bending) in the segment adjacent to the planned fusion - You have significant spinal imbalance (sagittal or coronal) - You have a spinal infection or tumor - You have had previous lumbar fusion surgery Talk to your spine surgeon if you are being considered for lumbar fusion surgery and want to understand how your overall spinal health may affect long-term outcomes.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

OTHERPre-existing degenerative factors at adjacent segment

Pre-existing degenerative factors at adjacent segment, including disc factors and canal stenosis factors


Locations(1)

Peking University Third Hospital

Beijing, Beijing Municipality, China

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NCT04467944


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