Degenerative Disc Disease Clinical Trials

43 recruitingLast updated: June 18, 2026

There are 43 actively recruiting degenerative disc disease clinical trials across 21 countries. Studies span Not Applicable, Phase 1, Phase 2, Phase 3, Early Phase 1, Phase 4. Top locations include Santa Monica, California, United States, Shreveport, Louisiana, United States, Eugene, Oregon, United States. Updated daily from ClinicalTrials.gov.


Degenerative Disc Disease Trials at a Glance

43 actively recruiting trials for degenerative disc disease are listed on ClinicalTrialsFinder across 6 cities in 21 countries. The largest study group is Not Applicable with 17 trials, with the heaviest enrollment activity in Santa Monica, Shreveport, and Eugene. Lead sponsors running degenerative disc disease studies include Synergy Spine Solutions, ApaTech Ltd, and Kuros Biosurgery AG.

Browse degenerative disc disease trials by phase

Treatments under study

About Degenerative Disc Disease Clinical Trials

Looking for clinical trials for Degenerative Disc Disease? There are currently 33 studies actively recruiting participants. Clinical trials offer access to new treatments before they are widely available, and every approved therapy in use today was first tested through a clinical trial.

Below you can browse trials, sign up for alerts when new Degenerative Disc Disease trials open, and view eligibility criteria for each study. Each listing includes the study phase, locations, and enrollment details.

Frequently Asked Questions

Common questions about Degenerative Disc Disease clinical trials

A clinical trial is a carefully designed research study that tests new medical treatments, drugs, devices, or approaches in human volunteers. Every approved medication and treatment available today was proven safe and effective through clinical trials.

All clinical trials are reviewed and approved by Institutional Review Boards (IRBs) — independent committees that evaluate patient safety. Trials follow strict protocols, and your health is monitored closely throughout. You can withdraw at any time.

Not necessarily. Many trials compare the new treatment against the current standard of care, meaning all participants receive active treatment. When placebos are used, they are typically combined with standard treatment, not given alone. The trial description will always specify the design.

Under the Affordable Care Act, most private insurers are required to cover routine patient care costs during a clinical trial. The sponsor typically covers the investigational treatment itself. Medicare also covers routine costs for qualifying trials.

Yes. Participation is completely voluntary. You can withdraw at any time, for any reason, without it affecting your access to standard medical care.

Each trial has specific eligibility criteria — including age, diagnosis, disease stage, prior treatments, and general health. Browse the trials listed above and check their eligibility sections. You can also contact the trial site directly to discuss your situation.

Showing 120 of 43 trials

Recruiting

OssDsign® Spine Registry Study ("Propel")

Spinal StenosisDegenerative Disc Disease
OssDsign450 enrolled15 locationsNCT05329129
Recruiting
Early Phase 1

Brain Mechanisms Supporting Cannabis-induced Pain Relief

Chronic Low Back Pain (CLBP)SciaticaLumbar Radiculopathy+4 more
University of California, San Diego100 enrolled1 locationNCT04982965
Recruiting
Not Applicable

"Lumbar Operatively Inserted PerQdisc Artificial Implant Following Nulcectomy" (LOPAIN2)

Chronic Low-back PainDegenerative Disc Disease
Spinal Stabilization Technologies72 enrolled10 locationsNCT05508360
Recruiting
Phase 1Phase 2

LDGraft in Single Level Anterior Lumbar Interbody Fusion (ALIF)

Degenerative Disc DiseaseLumbar Spine DegenerationSpine Disease+1 more
Locate Bio Pty Ltd40 enrolled3 locationsNCT06462729
Recruiting

PMCF Study on the Effectiveness and Safety of METROSAN Spinal Systems and BONEGRAFT Filling Materials

SpondylolisthesisSpinal StenosisSpinal Tumors+5 more
Metrosan End. ve Elk. Mek. Cihazlar ve Tibbi Malz. San. Tic. Ltd. Co.561 enrolled3 locationsNCT07615491
Recruiting
Not Applicable

Carbofix Pedicle Screw System: Evaluation of the Clinical and Radiographic Outcomes of the Use of a Carbon Fiber Device Compared to Titanium Devices in Patients Undergoing Spinal Arthrodesis for Degenerative Spinal Diseases

Degenerative Disc Disease
Istituto Ortopedico Rizzoli118 enrolled1 locationNCT06209684
Recruiting
Not Applicable

HYDRAFIL-D: HYDRogel Augmentation For Intervertebral Lumbar Discs

Degenerative Disc Disease (DDD)
ReGelTec, Inc.225 enrolled14 locationsNCT06011551
Recruiting
Phase 3

Efficacy and Safety of Novosis Putty in Transforaminal Lumbar Interbody Fusion for Patients With Lumbar Degenerative Disc Disease

Degenerative Disc Disease
CGBio Inc.316 enrolled5 locationsNCT07017634
Recruiting

Post-Market Data Collection to Evaluate the Performance of the Synergy Disc®

Cervical Degenerative Disc Disease
Synergy Spine Solutions50 enrolled2 locationsNCT06383962
Recruiting
Not Applicable

Clinical Trial Evaluating the Safety and Efficacy of Nucleus Pulposus Allograft in Participants With Degenerative Disc Disease

Degenerative Disc DiseaseDisc DegenerationLumbar Discogenic Pain
VIVEX Biologics, Inc.496 enrolled19 locationsNCT06778447
Recruiting
Phase 3

A Study to Evaluate the Effectiveness of IDCT (Intradiscal Cell Therapy) in Subjects With One Level, Symptomatic Mild to Moderate Lumbar Degenerative Disc Disease

Degenerative Disc Disease
DiscGenics, Inc.162 enrolled14 locationsNCT07254806
Recruiting
Not Applicable

Comparison of Clinical Outcomes, Complications Rate and Treatment Costs of Mini-TLIF and MIDLIF in the Treatment of Discogenic Low Back Pain

Lumbar Disc DegenerationDegenerative Disc Disease (DDD)Lumbar Degenerative Disease+1 more
Copernicus Memorial Hospital100 enrolled1 locationNCT07127380
Recruiting

Post-Market Clinical Follow-Up Study on the Safety and Performance of Ennovate® Cervical

Degenerative Disc DiseaseSpinal TumorSpine Fracture+2 more
Aesculap AG200 enrolled4 locationsNCT05296889
Recruiting
Not Applicable

Post Marketing Study of MagnetOs Easypack Putty Standalone Compared to Demineralized Bone Matrix or Fibers Mixed With Autograft in Patients Undergoing Posterolateral Lumbar Fusion

Spine FusionDegenerative Disc DiseaseBack Pain
Kuros Biosurgery AG60 enrolled6 locationsNCT04679844
Recruiting
Not Applicable

MagnetOs Flex Matrix Compared to Trinity Elite Mixed With Local Autograft in Patients Undergoing up to Four-level Instrumented Posterolateral Fusion

Spine FusionDegenerative Disc DiseaseLeg Pain and/or Back Pain
Kuros Biosurgery AG100 enrolled7 locationsNCT05037968
Recruiting
Phase 1

Novel Soluble Epoxide Hydrolase Inhibitor for Neuropathic Pain in Patients With Spinal Cord Injury

Spinal StenosisDegenerative Disc DiseaseSpinal Cord Injuries+2 more
EicOsis Human Health Inc.36 enrolled1 locationNCT06438471
Recruiting
Phase 4

Regional Anesthesia in Minimally Invasive Lumbar Spine Surgery

Lumbar RadiculopathyDegenerative Disc DiseaseLumbar Spinal Stenosis+7 more
John O'Toole125 enrolled1 locationNCT05029726
Recruiting
Phase 1Phase 2

Safety, Tolerability, and Effectiveness of Intramuscular Injection of CELZ-201-DDT for the Treatment of Chronic Lower Back Pain

Chronic Low-back PainDegenerative Disc Disease
Creative Medical Technology Holdings Inc45 enrolled1 locationNCT06053242
Recruiting

Comparison of Artificial Disc Implants in Cervical Disc Arthroplasty

Cervical radiculopathyDegenerative Disc DiseaseCervical Disc Herniation+1 more
University of California, Los Angeles20 enrolled1 locationNCT05701059
Recruiting
Phase 3

Efficacy and Safety of Rexlemestrocel-L Combined With HA* in Participants With Moderate to Severe Chronic Low Back Pain

Degenerative Disc Disease
Mesoblast, Ltd.300 enrolled39 locationsNCT06325566