Degenerative Disc Disease Clinical Trials

30 recruiting

Degenerative Disc Disease Trials at a Glance

38 actively recruiting trials for degenerative disc disease are listed on ClinicalTrialsFinder across 6 cities in 19 countries. The largest study group is Not Applicable with 16 trials, with the heaviest enrollment activity in Santa Monica, Hartford, and Eugene. Lead sponsors running degenerative disc disease studies include Synergy Spine Solutions, ApaTech Ltd, and Kuros Biosurgery AG.

Browse degenerative disc disease trials by phase

Treatments under study

About Degenerative Disc Disease Clinical Trials

Looking for clinical trials for Degenerative Disc Disease? There are currently 30 studies actively recruiting participants. Clinical trials offer access to new treatments before they are widely available, and every approved therapy in use today was first tested through a clinical trial.

Below you can browse trials, sign up for alerts when new Degenerative Disc Disease trials open, and view eligibility criteria for each study. Each listing includes the study phase, locations, and enrollment details.

Frequently Asked Questions

Common questions about Degenerative Disc Disease clinical trials

A clinical trial is a carefully designed research study that tests new medical treatments, drugs, devices, or approaches in human volunteers. Every approved medication and treatment available today was proven safe and effective through clinical trials.

All clinical trials are reviewed and approved by Institutional Review Boards (IRBs) — independent committees that evaluate patient safety. Trials follow strict protocols, and your health is monitored closely throughout. You can withdraw at any time.

Not necessarily. Many trials compare the new treatment against the current standard of care, meaning all participants receive active treatment. When placebos are used, they are typically combined with standard treatment, not given alone. The trial description will always specify the design.

Under the Affordable Care Act, most private insurers are required to cover routine patient care costs during a clinical trial. The sponsor typically covers the investigational treatment itself. Medicare also covers routine costs for qualifying trials.

Yes. Participation is completely voluntary. You can withdraw at any time, for any reason, without it affecting your access to standard medical care.

Each trial has specific eligibility criteria — including age, diagnosis, disease stage, prior treatments, and general health. Browse the trials listed above and check their eligibility sections. You can also contact the trial site directly to discuss your situation.

Showing 120 of 38 trials

Recruiting

Post-Market Data Collection to Evaluate the Performance of the Synergy Disc®

Cervical Degenerative Disc Disease
Synergy Spine Solutions50 enrolled2 locationsNCT06383962
Recruiting

OssDsign® Spine Registry Study ("Propel")

Spinal StenosisDegenerative Disc Disease
OssDsign450 enrolled15 locationsNCT05329129
Recruiting
Not Applicable

Clinical Trial Evaluating the Safety and Efficacy of Nucleus Pulposus Allograft in Participants With Degenerative Disc Disease

Degenerative Disc DiseaseDisc DegenerationLumbar Discogenic Pain
VIVEX Biologics, Inc.496 enrolled19 locationsNCT06778447
Recruiting
Phase 3

A Study to Evaluate the Effectiveness of IDCT (Intradiscal Cell Therapy) in Subjects With One Level, Symptomatic Mild to Moderate Lumbar Degenerative Disc Disease

Degenerative Disc Disease
DiscGenics, Inc.162 enrolled14 locationsNCT07254806
Recruiting

Post-Market Clinical Follow-Up Study on the Safety and Performance of Ennovate® Cervical

Degenerative Disc DiseaseSpinal TumorSpine Fracture+2 more
Aesculap AG200 enrolled4 locationsNCT05296889
Recruiting
Not Applicable

Post Marketing Study of MagnetOs Easypack Putty Standalone Compared to Demineralized Bone Matrix or Fibers Mixed With Autograft in Patients Undergoing Posterolateral Lumbar Fusion

Spine FusionDegenerative Disc DiseaseBack Pain
Kuros Biosurgery AG60 enrolled6 locationsNCT04679844
Recruiting
Not Applicable

"Lumbar Operatively Inserted PerQdisc Artificial Implant Following Nulcectomy" (LOPAIN2)

Chronic Low-back PainDegenerative Disc Disease
Spinal Stabilization Technologies72 enrolled10 locationsNCT05508360
Recruiting
Not Applicable

MagnetOs Flex Matrix Compared to Trinity Elite Mixed With Local Autograft in Patients Undergoing up to Four-level Instrumented Posterolateral Fusion

Spine FusionDegenerative Disc DiseaseLeg Pain and/or Back Pain
Kuros Biosurgery AG100 enrolled7 locationsNCT05037968
Recruiting
Phase 1

Novel Soluble Epoxide Hydrolase Inhibitor for Neuropathic Pain in Patients With Spinal Cord Injury

Spinal StenosisDegenerative Disc DiseaseSpinal Cord Injuries+2 more
EicOsis Human Health Inc.36 enrolled1 locationNCT06438471
Recruiting
Phase 1Phase 2

Safety, Tolerability, and Effectiveness of Intramuscular Injection of CELZ-201-DDT for the Treatment of Chronic Lower Back Pain

Chronic Low-back PainDegenerative Disc Disease
Creative Medical Technology Holdings Inc45 enrolled1 locationNCT06053242
Recruiting
Phase 4

Regional Anesthesia in Minimally Invasive Lumbar Spine Surgery

Lumbar RadiculopathyDegenerative Disc DiseaseLumbar Spinal Stenosis+7 more
John O'Toole125 enrolled1 locationNCT05029726
Recruiting
Not Applicable

HYDRAFIL-D: HYDRogel Augmentation For Intervertebral Lumbar Discs

Degenerative Disc Disease (DDD)
ReGelTec, Inc.225 enrolled12 locationsNCT06011551
Recruiting
Phase 1Phase 2

LDGraft in Single Level Anterior Lumbar Interbody Fusion (ALIF)

Degenerative Disc DiseaseLumbar Spine DegenerationSpine Disease+1 more
Locate Bio Pty Ltd40 enrolled3 locationsNCT06462729
Recruiting
Phase 3

Efficacy and Safety of Rexlemestrocel-L Combined With HA* in Participants With Moderate to Severe Chronic Low Back Pain

Degenerative Disc Disease
Mesoblast, Ltd.300 enrolled39 locationsNCT06325566
Recruiting

Conduit Cages and Fibergraft BG Putty

Degenerative Disc DiseaseHerniated Disc
Nitin Agarwal100 enrolled1 locationNCT06704919
Recruiting

Real World Data Collection on the Synergy Disc

Cervical Degenerative Disc Disease
Synergy Spine Solutions50 enrolled1 locationNCT06383949
Recruiting

Post Market Data Collection Protocol to Evaluate the Performance of the Synergy Disc

Cervical Degenerative Disc Disease
Synergy Spine Solutions50 enrolled1 locationNCT05880823
Recruiting
Not Applicable

ACDF Using Structural Allograft vs. Tritanium C

Degenerative Disc Disease
Allegheny Singer Research Institute (also known as Allegheny Health Network Research Institute)60 enrolled1 locationNCT04388332
Recruiting

OssiMend BA in Posterolateral Instrumented Lumbar Fusion

Degenerative Disc DiseaseSpinal Disease
Collagen Matrix120 enrolled4 locationsNCT04775537
Recruiting
Not Applicable

Investigation of DEXA-C Anterior Cervical Interbody System

Degenerative Disc Disease
Aurora Spine and Pain80 enrolled4 locationsNCT05883436