RecruitingNot ApplicableNCT04469387

Preventive Effect of Limited Decompression on Adjacent Segment Following Posterior Lumbar Interbody Fusion

Preventive Effect of Limited Decompression on Adjacent Segment With Pre-existing Spinal Canal Stenosis Following Posterior Lumbar Interbody Fusion: a Prospective Interventional Study


Sponsor

Peking University Third Hospital

Enrollment

200 participants

Start Date

Sep 1, 2020

Study Type

INTERVENTIONAL

Conditions

Summary

This is a prospective single-center study. Patients requiring posterior lumbar interbody fusion (PLIF) for degenerative disease are prospectively enrolled and followed. Patients enrolled in this study have asymptomatic pre-existing spinal canal stenosis at adjacent segment. This study will focus on the effects of preventative limited decompression at adjacent segment.


Eligibility

Min Age: 18 YearsMax Age: 80 Years

Plain Language Summary

Simplified for easier understanding

This surgical study evaluates whether performing a limited decompression at the spinal segment adjacent to a lumbar fusion — while the fusion itself is being done — can prevent or delay the development of adjacent segment disease. Adjacent segment disease is a recognized complication after spinal fusion, where the discs and joints next to the fused level degrade faster. This proactive approach may reduce the likelihood of needing another operation in the future. You may be eligible if... - You have lumbar spinal stenosis requiring surgery at the L4-S1 level - You have asymptomatic narrowing of the spinal canal at the adjacent segment (L3/L4) - You have not responded to at least 8 weeks of conservative treatment You may NOT be eligible if... - You have spinal instability at the adjacent segment - You have significant spinal imbalance - You have spinal infection or tumors - You have had a previous lumbar fusion surgery Talk to your spine surgeon if you are scheduled for lumbar fusion and are concerned about the long-term health of adjacent spinal levels. This preventive surgical approach is being studied to help reduce future operations.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

PROCEDURELimited decompressions at adjacent segment with asymptomatic pre-existing spinal canal stenosis

In terms of limited decompression at the adjacent segment, partial laminotomy, flavectomy, and bilateral medial facetectomies up to the pedicle will be performed. Complete laminectomy and destroy of posterior ligament complex will be avoided.

PROCEDUREResponsible segments fused

In terms of responsible segments fused, L4-5 and L5-S1 were fused using posterior lumbar interbody fusion (PLIF).


Locations(1)

Peking University Third Hospital

Beijing, Beijing Municipality, China

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NCT04469387


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