RecruitingNot ApplicableNCT04469790

Effects of Multi-day Interruptions in Sitting on Type 2 Diabetes-relevant Outcomes in Children

Testing the Efficacy of Multi-day Interruptions in Sedentary Behaviors on Metabolic, Cognitive, and Affective Outcomes in Youth at Risk for Type 2 Diabetes

Sponsor

University of Southern California

Enrollment

188 participants

Start Date

Mar 1, 2022

Study Type

INTERVENTIONAL

Conditions

Metabolic Disturbance Sedentary Behavior Anxiety Affect Cardiac Autonomic Nervous System Function

Summary

The overall objective of this in-lab randomized controlled trial is to test the efficacy of multi-day interruptions in sedentary behavior vs. single bouts of sustained exercise on metabolic, cognitive, affective, and cardiac autonomic nervous system responses in children with overweight and obesity who are at risk for type 2 diabetes. The use of continuous glucose monitoring will provide insight into the daily and cumulative metabolic effects of each condition that have thus far not been studied. In-lab studies demonstrating sustained efficacy of this approach in ameliorating negative effects of sedentary behaviors in children are necessary for the optimization of field-based interventions. Given the lack of success of interventions to prevent obesity-related diseases and increasing rates of type 2 diabetes in children and its related healthcare costs, this study addresses a critical public health need by testing of novel intervention strategies to reduce obesity-related diseases in children with overweight and obesity.

Eligibility

Min Age: 8 YearsMax Age: 11 Years

Plain Language Summary

Simplified for easier understanding

This study is looking at whether taking breaks from prolonged sitting over multiple days can improve blood sugar levels and other metabolic markers in overweight children. With childhood obesity and Type 2 diabetes on the rise, researchers want to understand if simply moving more throughout the day can make a measurable difference. **You may be eligible if:** - Your child is between 8 and 11 years old - Your child is generally healthy - Your child's BMI is at or above the 85th percentile for their age (overweight range) **You may NOT be eligible if:** - Your child has a significant heart or lung condition - Your child has been diagnosed with Type 2 diabetes or a hormone condition that causes obesity (like Cushing syndrome) - Your child takes antipsychotic medications - Your child is being treated for high blood pressure or high cholesterol with non-diet treatments - Your child has precocious puberty or is receiving hormone therapy - Your child is on medications that affect body weight or composition Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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