Affect Clinical Trials

120 recruitingLast updated: June 18, 2026

There are 120 actively recruiting affect clinical trials across 22 countries. Studies span Not Applicable, Phase 4, Phase 2, Phase 1, Phase 3. Top locations include Boston, Massachusetts, United States, Pittsburgh, Pennsylvania, United States, Dallas, Texas, United States. Updated daily from ClinicalTrials.gov.


Affect Trials at a Glance

120 actively recruiting trials for affect are listed on ClinicalTrialsFinder across 6 cities in 22 countries. The largest study group is Not Applicable with 63 trials, with the heaviest enrollment activity in Boston, Pittsburgh, and Dallas. Lead sponsors running affect studies include Centre for Addiction and Mental Health, Mclean Hospital, and VA Office of Research and Development.

Browse affect trials by phase

Treatments under study

About Affect Clinical Trials

Looking for clinical trials for Affect? There are currently 2 studies actively recruiting participants. Clinical trials offer access to new treatments before they are widely available, and every approved therapy in use today was first tested through a clinical trial.

Below you can browse trials, sign up for alerts when new Affect trials open, and view eligibility criteria for each study. Each listing includes the study phase, locations, and enrollment details.

Frequently Asked Questions

Common questions about Affect clinical trials

A clinical trial is a carefully designed research study that tests new medical treatments, drugs, devices, or approaches in human volunteers. Every approved medication and treatment available today was proven safe and effective through clinical trials.

All clinical trials are reviewed and approved by Institutional Review Boards (IRBs) — independent committees that evaluate patient safety. Trials follow strict protocols, and your health is monitored closely throughout. You can withdraw at any time.

Not necessarily. Many trials compare the new treatment against the current standard of care, meaning all participants receive active treatment. When placebos are used, they are typically combined with standard treatment, not given alone. The trial description will always specify the design.

Under the Affordable Care Act, most private insurers are required to cover routine patient care costs during a clinical trial. The sponsor typically covers the investigational treatment itself. Medicare also covers routine costs for qualifying trials.

Yes. Participation is completely voluntary. You can withdraw at any time, for any reason, without it affecting your access to standard medical care.

Each trial has specific eligibility criteria — including age, diagnosis, disease stage, prior treatments, and general health. Browse the trials listed above and check their eligibility sections. You can also contact the trial site directly to discuss your situation.

Showing 120 of 120 trials

Recruiting
Phase 4

A Study to Evaluate the Effectiveness of Valbenazine in Adult Participants With Tardive Dyskinesia (TD) Who Remain Symptomatic While Receiving or After Stopping a Vesicular Monoamine Transporter 2 (VMAT2) Inhibitor

SchizophreniaMajor Depressive DisorderBipolar Disorder+2 more
Neurocrine Biosciences50 enrolled22 locationsNCT07105111
Recruiting
Phase 2

Neurotransmitters in Treatment Resistant Schizophrenia Patients With add-on Sodium Benzoate

SchizophreniaSchizo Affective DisorderSymptom, Cognitive
National Cheng-Kung University Hospital90 enrolled1 locationNCT06340789
Recruiting
Not Applicable

Neural Mechanisms of Interpersonal Expectations on Negative Affect

Placebo effectNegative AffectivityNon-invasive Brain Stimulation+1 more
Trustees of Dartmouth College196 enrolled1 locationNCT06980090
Recruiting
Phase 3

Effect of Preventive Analgesia by Injection of a Local Anesthetic Before Vaginal Incision for Hysterectomy by vNOTES Approach

Hysterotomy; Affecting Fetus
University Hospital, Rouen108 enrolled2 locationsNCT05969457
Recruiting
Phase 4

Bazedoxifene -Treatment for Women With Schizophrenia

SchizophreniaSchizo Affective DisorderSchizophreniform Disorders
The Alfred160 enrolled1 locationNCT04113993
Recruiting
Not Applicable

Exploring the Feasibility of Transcranial Ultrasound Stimulation in the Treatment of Schizophrenia

Schizo Affective Disorder
Far Eastern Memorial Hospital80 enrolled1 locationNCT07621549
Recruiting
Phase 4

Metabolic Effects of Adjunctive Lumateperone Treatment in Clozapine-Treated Patients With Schizophrenia

SchizophreniaSchizo Affective Disorder
University of Massachusetts, Worcester50 enrolled1 locationNCT06174116
Recruiting
Not Applicable

Trauma-adapted Yoga in Child & Adolescent Psychiatry.

PainQuality of LifePTSD+3 more
University West, Sweden180 enrolled1 locationNCT06330779
Recruiting
Phase 4

CLOZAPINE Response in Biotype-1

SchizophreniaSchizoaffective DisorderBipolar 1 Disorder
University of Texas Southwestern Medical Center524 enrolled5 locationsNCT04580134
Recruiting
Phase 2

Melatonin Versus Placebo for Bipolar Disorder

Bipolar Affective Disorder
Lars Vedel Kessing200 enrolled1 locationNCT07472075
Recruiting

Medical Phenotyping of NHS General Adult Psychiatry (GAP) Inpatients

Schizophrenia DisordersPersonality DisordersDepression Disorders+1 more
University of Edinburgh100 enrolled1 locationNCT07398365
Recruiting
Phase 2

Training Reward Responsiveness Through Virtual Reality

DepressionPositive Affect
University of California, Los Angeles80 enrolled1 locationNCT07219875
Recruiting
Phase 4

Clozapine for the Prevention of Violence in Schizophrenia: a Randomized Clinical Trial

SchizophreniaSchizoaffective Disorder
New York State Psychiatric Institute280 enrolled7 locationsNCT05208190
Recruiting

Validation and Impact of Cardiorespiratory Fitness in Severe Mental Illness - the Heart in Mind Project

Bipolar Affective DisorderSevere Mental IllnessSchizophrenia Spectrum & Other Psychotic Disorders
Bjorn H. Ebdrup75 enrolled1 locationNCT06743711
Recruiting
Not Applicable

Manipulating Exercise Intensity and Affective Responses for Cardiac Rehabilitation Program Acute Coronary Syndrome Patients

Affect and Exertion During and Post-exercise
Instituto Politécnico de Leiria52 enrolled2 locationsNCT07105943
Recruiting

Database Registry for Neural Network Biomarkers in Psychosis

SchizophreniaSchizoaffective Disorder
University of Texas Southwestern Medical Center1,000 enrolled1 locationNCT01409109
Recruiting
Not Applicable

ETASCAN Project: ETAS Project 2

MRISleepCognition+3 more
University of Reading60 enrolled1 locationNCT07550140
Recruiting

Cognitive Function and Affective Regulation in Meditators

Cognitive Function and Affective Regulation
Balachundhar Subramaniam104 enrolled1 locationNCT07546786
Recruiting
Not Applicable

Examining the Efficacy of a Virtual Reality Cognitive Remediation Program for People Living With Psychosis

SchizophreniaPsychotic DisordersSchizo Affective Disorder
The Royal Ottawa Mental Health Centre52 enrolled1 locationNCT05973110
Recruiting
Not Applicable

Castor Oil Ingestion and Balloon Catheter for Labor Induction in Nulliparous

Induction of Labor Affected Fetus / Newborn
Holy Family Hospital, Nazareth, Israel142 enrolled2 locationsNCT06325007