Prostate Cancer Screening for People at Genetic Risk for Aggressive Disease, PATROL Study

This study is offering prostate cancer screening to people who have a known genetic mutation that increases their risk of developing aggressive prostate cancer. Because standard screening guidelines may not apply to high-genetic-risk individuals, this study aims to find the best early detection approach for this group. **You may be eligible if:** - You have a prostate and are 40 years of age or older - You have a confirmed inherited gene mutation known to increase prostate cancer risk (such as BRCA1, BRCA2, or others) **You may NOT be eligible if:** - You have already been diagnosed with prostate cancer - You have a medical condition that prevents you from safely undergoing the study procedures (such as prostate biopsy) - You received cancer treatment with curative intent within the past 12 months (for any cancer except non-melanoma skin cancer) - You have participated in another prostate cancer prevention trial for people with inherited genetic mutations Talk to your doctor to see if this trial is right for you.