RecruitingNCT04477785

PPMI Clinical - Establishing a Deeply Phenotyped PD Cohort

The Parkinson's Progression Markers Initiative (PPMI) Clinical - Establishing a Deeply Phenotyped PD Cohort

Sponsor

Michael J. Fox Foundation for Parkinson's Research

Enrollment

4,500 participants

Start Date

Jul 1, 2020

Study Type

OBSERVATIONAL

Conditions

Parkinson Disease

Summary

The Parkinson Progression Marker Initiative (PPMI) is a longitudinal, observational, multi-center natural history study to assess progression of clinical features, digital outcomes, and imaging, biologic and genetic markers of Parkinson's disease (PD) progression in study participants with manifest PD, prodromal PD, and healthy controls. The overall goal of PPMI is to identify markers of disease progression for use in clinical trials of therapies to reduce progression of PD disability.

Eligibility

Min Age: 30 Years

Plain Language Summary

Simplified for easier understanding

This is a large, long-term research study building a detailed database of people with Parkinson's disease and related conditions, as well as healthy volunteers. The goal is to better understand why Parkinson's develops, how it progresses, and what factors affect outcomes — helping researchers develop better treatments. **You may be eligible if...** - You have been diagnosed with Parkinson's disease or a related condition (such as REM sleep behavior disorder or a genetic risk for Parkinson's) - You are a healthy volunteer aged 57 or older with no Parkinson's diagnosis - You are able to participate in brain scans and regular assessments **You may NOT be eligible if...** - You are unable to provide informed consent - You have conditions that would interfere with required brain imaging (SPECT scans) - You are a healthy volunteer under 57 years old Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

Interested in this trial?

Get notified about updates and connect with the research team.

Locations(50)

University of Alabama at Birmingham

Birmingham, Alabama, United States

Barrow Neurological Institute

Phoenix, Arizona, United States

Mayo Foundation for Medical Education and Research

Scottsdale, Arizona, United States

Banner Research Institute

Sun City, Arizona, United States

University of California San Diego

La Jolla, California, United States

Keck School of Medicine of USC

Los Angeles, California, United States

University of California, San Francisco

San Francisco, California, United States

University of Colorado Anschutz Medical Campus

Aurora, Colorado, United States

Institute For Neurodegenerative Disorders

New Haven, Connecticut, United States

Parkinson's Disease& Movement Disorder Center of Boca Raton

Boca Raton, Florida, United States

University of Florida

Gainesville, Florida, United States

University of South Florida

Tampa, Florida, United States

Emory University School of Medicine

Atlanta, Georgia, United States

Northwestern University

Chicago, Illinois, United States

University of Kansas Medical Center

Kansas City, Kansas, United States

Johns Hopkins University

Baltimore, Maryland, United States

Boston University

Boston, Massachusetts, United States

Massachusetts General Hospital

Boston, Massachusetts, United States

University of Michigan

Ann Arbor, Michigan, United States

Cleveland Clinic Lou Ruvo Center for Brain Health

Las Vegas, Nevada, United States

Beth Israel Medical Center

New York, New York, United States

NYU Langone Health

New York, New York, United States

University of Rochester

Rochester, New York, United States

University of Cincinnati/Cincinnati Children's Hospital

Cincinnati, Ohio, United States

Cleveland Clinic

Cleveland, Ohio, United States

Oregon Health &Science University

Portland, Oregon, United States

University of Pennsylvania

Philadelphia, Pennsylvania, United States

University of Pittsburgh

Pittsburgh, Pennsylvania, United States

Baylor College of Medicine

Houston, Texas, United States

Univ of Washington and VA Puget Sound Health Care System

Seattle, Washington, United States

Innsbruck Medical University

Innsbruck, Austria

The Ottawa Hospital - Civic Campus

Ottawa, Ontario, Canada

Toronto Western Hospital

Toronto, Ontario, Canada

McGill University

Montreal, Quebec, Canada

Philipps-University of Marburg

Hessen, Germany

Paracelsus-Elena Klinik

Kassel, Germany

University of Luebeck

Lübeck, Germany

University of Tuebingen

Tübingen, Germany

Foundation for Biomedical Research of the Academy of Athens

Athens, Athens, Greece

Tel Aviv Sourasky Medical Center

Tel Aviv, Tel Aviv, Israel

University of Salerno

Salerno, Salerno, Italy

Parkinson Research Clinic

Luxembourg, Luxembourg

Radboud University

Nijmegen, Gelderland, Netherlands

Lagos College of Medicine, University of Lagos

Lagos, Lagos, Nigeria

Hospital Clinic de Barcelona

Barcelona, Barcelona, Spain

Hospital Donostia

Donostia / San Sebastian, San Sebastian, Spain

Queen Mary University of London

London, Britain, United Kingdom

Newcastle University

Newcastle upon Tyne, Tyne and Wear, United Kingdom

Imperial College London

London, United Kingdom

John Radcliffe Hospital Oxford and Oxford University

Oxford, United Kingdom

View Full Details on ClinicalTrials.gov

For the most up-to-date information, visit the official listing.

Visit

NCT04477785

Related Trials

Brain Training to Improve Balance in Parkinson's Disease

NCT059866431 location

tDCS on Parkinson's Disease Cognition

NCT030253341 location

The University of Alabama at Birmingham (UAB) Neuroinflammation in Parkinson's Disease-TSPO- Positron Emission Tomography (PET) Substudy

NCT034574931 location

World Data on Ambroxol for Patients With GD and GBA Related PD

NCT043889693 locations

A Phase 2 Study and Open-Label Extension of NEU-411 in Companion Diagnostic-Positive Participants With Early Parkinson's Disease

NCT0668083070 locations