Selective Internal Radiation Therapy With 90Y Resin Micropheres for Refractory Colorectal Cancer Liver Metastases

This study tests a targeted liver radiation therapy called SIRT (Selective Internal Radiation Therapy), using tiny radioactive beads (yttrium-90 microspheres) delivered directly into the liver's blood supply, for patients with colorectal cancer that has spread to the liver and has not responded to standard chemotherapy. **You may be eligible if...** - You are 18 or older with metastatic colorectal cancer that is primarily in the liver - Your liver metastases cannot be removed by surgery or other local treatments - Your cancer has progressed or you could not tolerate all standard chemotherapy options - You have good performance status (ECOG 0–1) **You may NOT be eligible if...** - You have active chemotherapy within 14 days of treatment (or anti-VEGF drugs within 6 weeks) - Your cancer has spread extensively outside the liver - Your liver function or blood flow does not support the procedure Talk to your doctor to see if this trial is right for you.