RecruitingNot ApplicableNCT04502225

Effect of Raised Head of the Bed on Lying Blood Pressure in Autonomic Failure

Impact of Decreased Venous Return on Supine Blood Pressure


Sponsor

Vanderbilt University Medical Center

Enrollment

44 participants

Start Date

Aug 21, 2020

Study Type

INTERVENTIONAL

Conditions

Summary

Many persons with autonomic failure often have high blood pressure when lying down (supine hypertension). This study is exploring the impact of decreased venous return to the heart (achieved by raising the head of the bed) to lessen supine blood pressure. If decreased venous return to the heart is effective at lowering supine blood pressure, these approaches may be utilized to treat supine hypertension non-pharmacologically. Raising the head of the bed decreases the amount of blood returning to the heart due to the effects of gravity. In this case, the decreased blood return to the heart may decrease blood pressure.


Eligibility

Min Age: 18 YearsMax Age: 85 Years

Plain Language Summary

Simplified for easier understanding

This study tests whether simply raising the head of the bed at night can lower dangerously high blood pressure that occurs when lying flat in people with autonomic failure — a condition where the nervous system cannot properly regulate blood pressure. **You may be eligible if...** - You have been diagnosed with autonomic failure - You experience high blood pressure when lying down (supine hypertension) - You are between 18 and 85 years old **You may NOT be eligible if...** - You are a medical student (excluded per protocol) - You are pregnant - You have heart failure, symptomatic coronary artery disease, liver disease, or a history of stroke or heart attack - You have serious allergies or severe asthma Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

Interested in this trial?

Get notified about updates and connect with the research team.

Interventions

OTHERTilt

Tilt of the whole bed so that the head is elevated by 9 and/or 12 inches in an acute trial or overnight.

OTHERElevated trunk

Elevation of the trunk through raising just the head of the bed until the head is elevated by 9 and/or 12 inches in an acute trial or overnight.

OTHERTilt - In home

Tilt of the whole bed so that the head is elevated by 8 inches overnight.

OTHERElevated Trunk - In home

Elevation of the trunk through raising the head 8 inches on a wedge pillow overnight.


Locations(1)

Vanderbilt University Medical Center

Nashville, Tennessee, United States

View Full Details on ClinicalTrials.gov

For the most up-to-date information, visit the official listing.

Visit

NCT04502225


Related Trials