RecruitingNCT04504747

Real Time Molecular Analysis of Breast Cancer Receiving Neo-adjuvant Chemotherapy

Real Time Molecular Analysis of Breast Cancer Receiving Neo-adjuvant Chemotherapy: Identification of Preclinical Models Predictive for Therapeutic Resistance

Sponsor

Institut Paoli-Calmettes

Enrollment

150 participants

Start Date

Nov 3, 2022

Study Type

OBSERVATIONAL

Conditions

Breast Cancer Female

Summary

The present project aims at identifying robust candidates for drug resistance in BC patients eligible for NAC. Its originality lies upon the combination of three different and complementary prospective approaches: from the molecular analyses of biopsies sampled before and after NAC, from in vitro BC Patient-Derived Organoids (PDO) mimicking patient's response to NAC, and from Circulating Tumor Cells (CTCs) isolated before/during/after NAC.

Eligibility

Sex: FEMALEMin Age: 18 Years

Plain Language Summary

Simplified for easier understanding

This study performs real-time molecular testing on breast cancer tissue taken during neoadjuvant chemotherapy (chemo given before surgery) to better understand how the tumor responds to treatment. The information may help guide surgical and radiation decisions. **You may be eligible if...** - You are a woman over 18 - You have a confirmed diagnosis of invasive breast cancer - Your treatment team has recommended neoadjuvant chemotherapy (chemo before surgery) followed by surgery and then radiation - You are able to have a biopsy as part of the study **You may NOT be eligible if...** - You have a condition that prevents biopsy - Your treatment plan does not include the full sequence of chemotherapy, surgery, and radiation - You are in poor overall health (WHO performance status above 1) - You are not affiliated with a social security scheme (requirement specific to the French health system) Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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