Intravenous Dexamethasone Administration in Patients Undergoing Total Shoulder Arthroplasty

This trial examines whether a single intravenous dose of dexamethasone (a steroid) given during total shoulder replacement surgery can reduce post-operative pain, nausea, and inflammation, and improve recovery. Dexamethasone is already commonly used in some surgeries for these purposes, but its benefit in total shoulder arthroplasty has not been well-studied in a controlled trial. Participants are adults aged 58–85 having their first total shoulder replacement (anatomical or reverse) with a BMI between 18.5 and 35. Patients with diabetes, certain chronic conditions, or who need revision surgery are excluded. You may be eligible if: - You are between 58 and 85 years old - You are having a primary (first-time) total shoulder replacement - Your BMI is between 18.5 and 35 - You can provide informed consent and follow study procedures You may NOT be eligible if: - You have contraindications to steroids or NSAIDs - You have uncontrolled diabetes - You have an active autoimmune disease (e.g., lupus, rheumatoid arthritis) - You have been on steroid or immunosuppressive therapy in the last 30 days - You are pregnant or breastfeeding - You are having revision or post-traumatic shoulder replacement - You have severe systemic illness (ASA class IV) Talk to your doctor to see if this trial is right for you.