RecruitingPhase 2NCT04510636

Study of Pembrolizumab With Bendamustine in Hodgkin Lymphoma

Phase 2 Study Evaluating the Safety and Efficacy of Pembrolizumab (KEytruda) in Combination With Bendamustine (TREanda) in Relapsed/Refractory Hodgkin Lymphoma


Sponsor

University Health Network, Toronto

Enrollment

37 participants

Start Date

Dec 20, 2021

Study Type

INTERVENTIONAL

Conditions

Summary

This is a phase 2 open-label study to test the safety and effectiveness of combining pembrolizumab and bendamustine in patients with relapsed (cancer that has come back or started getting worse) or refractory (cancer that is not responding or has stopped responding to treatment) Hodgkin lymphoma.


Eligibility

Min Age: 18 Years

Plain Language Summary

Simplified for easier understanding

This study tests a combination of pembrolizumab (an immunotherapy drug) and bendamustine (a chemotherapy drug) for classical Hodgkin lymphoma that has come back or is not responding to standard treatments. **You may be eligible if...** - You have a confirmed diagnosis of classical Hodgkin lymphoma that has relapsed or is refractory (not responding) - You have received at least one prior standard treatment - You are 18 or older and in adequate overall health - You have measurable disease on imaging **You may NOT be eligible if...** - You have had prior treatment with pembrolizumab or similar checkpoint inhibitor drugs - You have active autoimmune disease - You have significant heart, kidney, or liver problems - You are pregnant or breastfeeding Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

DRUGPembrolizumab

Pembrolizumab is a intravenously administered humanized monoclonal antibody that blocks the interaction between PD-1 and its ligands, PD-L1 and PD-L2.

DRUGBendamustine Hydrochloride

Bendamustine is a unique alkylating agent with substantial activity in hematologic malignancies.


Locations(1)

Princess Margaret Cancer Centre

Toronto, Ontario, Canada

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NCT04510636


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