RecruitingNCT04529967

Child-Parent Familial Hypercholesterolemia Screening

Child-Parent Screening of Familial Hypercholesterolemia in Children


Sponsor

Children's Hospital of Fudan University

Enrollment

15,000 participants

Start Date

Apr 1, 2025

Study Type

OBSERVATIONAL

Conditions

Summary

Child-parent screening for familial hypercholesterolemia has been proposed to identify children and their parent who are carrier of mutations and with high risk for inherited premature coronary artery disease. The investigators assessed the efficacy and feasibility of such screening in primary care practice. key scientific questions: 1. The 95th and 99th percentile of finger blood TC in children of 2 years old. 2. Mutations that contribute to high TC status ( serum TC \>99th percentiles) compared with international FH48 panel for FH genetic screening.


Eligibility

Min Age: 1 YearMax Age: 3 Years

Plain Language Summary

Simplified for easier understanding

This study is screening young children for familial hypercholesterolemia (FH) — an inherited condition that causes very high cholesterol from birth, dramatically increasing the risk of early heart disease if left untreated. FH often goes undiagnosed for decades. This study uses the opportunity of routine childhood health visits to test children aged 1 to 3, and then tests their parents (cascade screening) if the child's cholesterol is high. Early identification allows families to make diet and lifestyle changes and, if necessary, start treatment early to protect the heart. You may be eligible if: - Your child is between 1 and 3 years old - Your child is receiving routine child care at a participating clinic You may NOT be eligible if: - The researcher determines participation is not suitable for your child (based on individual assessment) Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

OTHERno interventions

it is a observational study, do not have interventions.


Locations(6)

Anhui Provincial Children's Hospital

Hefei, Anhui, China

Qidong Women and Children Hospital

Qidong, Jiangsu, China

Weili Yan

Shanghai, Shanghai Municipality, China

Shanxi Provincial Children's Hospital

Taiyuan, Shanxi, China

Chongqin Medical University Affiliated Children's Hospital

Chongqing, Sichuan, China

Urumqi Children's Hospital

Ürümqi, Xinjiang, China

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NCT04529967


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