2-Hydroxybenzylamine (2-HOBA) to Reduce HDL Modification and Improve HDL Function in Familial Hypercholesterolemia (FH)

This study is testing whether a compound called 2-HOBA (2-hydroxybenzylamine) can improve the function of HDL cholesterol (the 'good' cholesterol) in people with familial hypercholesterolemia (FH) — a genetic condition that causes very high LDL ('bad') cholesterol from birth. In FH, HDL often becomes damaged and dysfunctional; 2-HOBA may prevent this damage and help HDL protect the heart. You may be eligible if... - You are between 18 and 69 years old - You have been diagnosed with heterozygous familial hypercholesterolemia You may NOT be eligible if... - You have had a heart attack or stroke in the last 6 months - You have unstable or recent angina (chest pain) - You have severe heart failure (NYHA class III or IV) or very poor heart function - You have poorly controlled high blood pressure - You are a current smoker - You have Type 2 diabetes, obesity (BMI above 30), high triglycerides, or kidney problems - You have liver disease, thyroid problems, rheumatoid arthritis, lupus, HIV, or nephrotic syndrome - You have a history of any cancer in the past 5 years Talk to your doctor to see if this trial is right for you.