RecruitingNot ApplicableNCT04531696

UZ/KU Leuven Program for Post-mortem Tissue Donation to Enhance Research

Sponsor

Universitaire Ziekenhuizen KU Leuven

Enrollment

100 participants

Start Date

Nov 30, 2020

Study Type

INTERVENTIONAL

Conditions

Breast Cancer Hereditary Diseases

Summary

UPTIDER is a prospective, interventional, non-Investigational Medicinal Product (non-IMP), non-commercial, single centre post-mortem tissue donation program for metastatic breast cancer patients or patients with a germline pathogenic variant with a moderate to high lifetime risk of breast cancer and at least one malignancy at time of death. The overarching objective of UPTIDER is (i) to unravel metastatic breast cancer evolution, biology, heterogeneity and treatment resistance and (ii) to assess pathogenicity and tumour biology in hereditary cancer syndromes with a high lifetime risk of breast cancer; both through extensive post-mortem multi-level and multi-region sample analysis.

Eligibility

Min Age: 18 Years

Plain Language Summary

Simplified for easier understanding

This program at UZ Leuven asks patients with advanced or hereditary breast cancer to donate tissue after death to support future research into breast cancer biology and treatments. **You may be eligible if...** - You are 18 or older - You have metastatic (spread) breast cancer, OR you have a hereditary condition that puts you at moderate to high lifetime risk of breast cancer - You are treated or followed at UZ Leuven, or referred there specifically for this program - You are willing to give informed consent for tissue donation **You may NOT be eligible if...** - You do not have metastatic breast cancer or a relevant hereditary cancer syndrome - You are not willing or able to provide consent for post-mortem donation Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

PROCEDUREBlood draw

Blood draw at inclusion

PROCEDUREPost-mortem tissue collection

Sample collection (both liquids, tumour tissue and non-tumour tissue) during post-mortem research autopsy

Locations(1)

UZ Leuven

Leuven, Belgium

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NCT04531696

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