Multimodal Neuroprognostication in Disorders of Consciousness
Assistance Publique - Hôpitaux de Paris
500 participants
Sep 9, 2020
OBSERVATIONAL
Conditions
Summary
Disorders of consciousness frequently occur at the acute phase of brain injuries. For the most severe cases, consciousness impairment can be prolonged. To optimize the medical plan and the goal of care, it is fundamental to have precise tools to predict chances of recovery of consciousness and potential disability. Currently, multimodal assessment including behavioral, neurophysiological and neuroimaging technics is recommended. However, the respective predictive values of these markers are poorly understood and decision making is challenging when results are contradictory
Eligibility
Inclusion Criteria3
- Consciousness disorder (acute sub-acute or chronic for which our expertise is requested to better characterize the diagnostic and prognosis of recovery)
- Brain injuries on CT or MRI (e.g. TBI) (traumatic brain-injured ), anoxia or stroke related lesions, etc…)
- Age between 18 and 80 years
Exclusion Criteria3
- Deep sedation (e.g. elevated ICP(intracranial pressure ), refractory status epilepticus)
- Sever known neurodegenerative disease (e.g. Alzheimer disease)
- Pregnancy
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Interventions
Based on the collected data, we will evaluate the respective diagnostic accuracy of all the markers acquired in clinical practice regarding the clinical outcome at 2 years.
Locations(1)
View Full Details on ClinicalTrials.gov
For the most up-to-date information, visit the official listing.
NCT04534777