RecruitingNCT05823454

Consciousness-specific Brain Network Connection of Propofol Sedation and Prolonged Disorders of Consciousness

Consciousness-specific Brain Network Connection of Propofol Sedation and Prolonged Disorders of Consciousness Based on Electroencephalogram and Event-related Potential

Sponsor

Beijing Tiantan Hospital

Enrollment

200 participants

Start Date

Sep 30, 2022

Study Type

OBSERVATIONAL

Conditions

Consciousness Disorder

Summary

Consciousness-specific Brain Network Connection of Propofol Sedation and Prolonged Disorders of Consciousness based on Electroencephalography and Auditory Event-related Potentials

Eligibility

Min Age: 18 YearsMax Age: 65 Years

Inclusion Criteria4

Age 18 - 65 years old, native Chinese speaker, dextromanuality;
Chronic disorder of consciousness;
Spinal cord electrical stimulator implantation under general anesthesia;
Signed informed consent.

Exclusion Criteria9

Continuous sedation was administered within 72 hours prior to the study;
Open head injury, parenchymatectomy and other damage of brain structural integrity;
The intracranial compliance decreased due to hydrocephalus and swelling;
Known hearing impairment;
Airway stenosis and various causes of severe ventilation or ventilation dysfunction;
Known or suspected cardiac dysfunction;
Allergic to intravenous general anesthetics;
Associated with other mental or neurological diseases;
Other reasons are not suitable to participate in this study.