RecruitingNCT04547673

To Develop and Validate a Nasoendoscopic Intelligent Diagnostic System for Nasopharyngeal Carcinoma

Sponsor

First Affiliated Hospital, Sun Yat-Sen University

Enrollment

1,000 participants

Start Date

Jun 20, 2020

Study Type

OBSERVATIONAL

Conditions

Artificial Intelligence Otolaryngological Disease

Summary

Nasopharyngeal carcinoma (NPC) occurs at a high frequency in southern China, northern Africa, and Alaska, with a reported incidence of 30 cases per 100 000 in Guangdong Province. Endoscopic examination and biopsy are the main methods used for detection and diagnosis of NPC. Early NPC patients achieve favourable prognoses after concurrent radiotherapy and chemotherapy in compassion with advanced NPC patients. Here, the investigators focused on the utility of artificial intelligence to detect early NPC, which based on white light imaging (WLI) and Narrow-band imaging (NBI) nasoendoscopic examination. Having access to this unique population provides an unprecedented opportunity to investigate the effect of intelligent system on diverse nasopharyngeal lesions detection and develop a novel Computer-Aided Diagnosis System.

Eligibility

Min Age: 18 Years

Plain Language Summary

Simplified for easier understanding

This study is developing and testing an AI-powered nasal endoscopy system that can help doctors more accurately detect and diagnose nasopharyngeal carcinoma (a cancer at the back of the nasal cavity) during routine scope examinations. **You may be eligible if...** - You are over 18 years old - You are undergoing nasal endoscopy - You are willing to sign the informed consent form **You may NOT be eligible if...** - You refuse to sign the consent form - You have contraindications to the procedure, such as a blood clotting disorder or a known drug allergy relevant to the procedure Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

DIAGNOSTIC_TESTrigid nasal endoscopes

The endoscope is introduced through the nasal passage to observe, in sequence, the posterior nostril, superior and posterior walls of the nasopharynx, torus tubarius, pharyngeal opening of the auditory tube, and Rosenmu¨ller recess. The imaging light mode is set to conventional WLI and subsequently switch to NBI during the procedure, and representative images are collected and preserve for further analysis. All lesions, detected by either WLI or NBI, are biopsied.