Comparison of Proton or Intensity Modulated Radiation Therapy After Surgery for Endometrial or Cervical Cancer

This study compares two types of radiation therapy — proton therapy and intensity-modulated radiation therapy (IMRT) — for women who have had surgery for cervical or endometrial cancer and need radiation to reduce the risk of recurrence. The goal is to find out which approach causes fewer side effects. **You may be eligible if...** - You have been diagnosed with cervical or endometrial cancer confirmed by biopsy - You have already had a hysterectomy (surgical removal of the uterus) - You are planned to receive radiation therapy to the pelvis at a Mayo Clinic site - You are in good enough health to receive radiation (ECOG 0-2) - You are willing to complete quality-of-life questionnaires **You may NOT be eligible if...** - Your cancer has spread to distant parts of the body - You have residual visible cancer remaining after surgery - You have had previous radiation to the pelvis - You have HIV/AIDS, severe liver disease, or a recent serious heart condition (heart attack or hospitalization for heart failure in the past 6 months) - Your tumor has a specific rare cell type (endometrial stromal sarcoma, leiomyosarcoma, melanoma, or small cell carcinoma) - You have had a prior invasive cancer in the last 3 years Talk to your doctor to see if this trial is right for you.