Sleep Spindles and Memory in Rolandic Epilepsy
Auditory Stimulation Effect on Spindles and Sleep Dependent Learning in Rolandic Epilepsy
Massachusetts General Hospital
100 participants
Jan 16, 2021
INTERVENTIONAL
Conditions
Summary
The investigators are recruiting children with Rolandic epilepsy and children without epilepsy (aged 4 years old and above) for a non-invasive brain imaging study using Magnetic Resonance Imaging (MRI), Magnetoencephalography/Electroencephalography (MEG/EEG), and experimental tasks. The investigators hope to determine the brain circuits and brain rhythms affected in these children and ultimately identify new treatment options for childhood epilepsy patients.
Eligibility
Inclusion Criteria4
- Ages 4-18 years
- Diagnosed with childhood epilepsy with centrotemporal spikes (CECTS) or Rolandic epilepsy by child neurologist
- Has EEG with sleep activated centrotemporal spikes
- Has had at least 1 focal motor or generalized seizure
Exclusion Criteria7
- Has abnormal brain MRI
- Has other unrelated neurological disease
- Unable to have an MRI/MEG
- Claustrophobic
- History of frequent vomiting
- Permanent metal in body, braces
- Over MRI weight limit: 350lbs
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Interventions
Quiet auditory stimulation timed with sleep physiology
Locations(1)
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NCT04569708