Epilepsy Clinical Trials

231 recruiting

Epilepsy Trials at a Glance

292 actively recruiting trials for epilepsy are listed on ClinicalTrialsFinder across 6 cities in 49 countries. The largest study group is Not Applicable with 124 trials, with the heaviest enrollment activity in Boston, Houston, and Paris. Lead sponsors running epilepsy studies include Xuanwu Hospital, Beijing, Fondation Ophtalmologique Adolphe de Rothschild, and Boston Children's Hospital.

Treatments under study

About Epilepsy Clinical Trials

Looking for clinical trials for Epilepsy? There are currently 231 studies actively recruiting participants. Clinical trials offer access to new treatments before they are widely available, and every approved therapy in use today was first tested through a clinical trial.

Below you can browse trials, sign up for alerts when new Epilepsy trials open, and view eligibility criteria for each study. Each listing includes the study phase, locations, and enrollment details.

Frequently Asked Questions

Common questions about Epilepsy clinical trials

A clinical trial is a carefully designed research study that tests new medical treatments, drugs, devices, or approaches in human volunteers. Every approved medication and treatment available today was proven safe and effective through clinical trials.

All clinical trials are reviewed and approved by Institutional Review Boards (IRBs) — independent committees that evaluate patient safety. Trials follow strict protocols, and your health is monitored closely throughout. You can withdraw at any time.

Not necessarily. Many trials compare the new treatment against the current standard of care, meaning all participants receive active treatment. When placebos are used, they are typically combined with standard treatment, not given alone. The trial description will always specify the design.

Under the Affordable Care Act, most private insurers are required to cover routine patient care costs during a clinical trial. The sponsor typically covers the investigational treatment itself. Medicare also covers routine costs for qualifying trials.

Yes. Participation is completely voluntary. You can withdraw at any time, for any reason, without it affecting your access to standard medical care.

Each trial has specific eligibility criteria — including age, diagnosis, disease stage, prior treatments, and general health. Browse the trials listed above and check their eligibility sections. You can also contact the trial site directly to discuss your situation.

Showing 120 of 292 trials

Recruiting
Phase 1

Investigation of Blood-Brain-Barrier Breakdown Using Manganese Magnetic Resonance Imaging in Drug-Resistant Epilepsy

Epilepsy
National Institute of Neurological Disorders and Stroke (NINDS)40 enrolled1 locationNCT02531880
Recruiting

Tumor Related Epilepsy

CancerEpilepsyBrain Neoplasm
National Institute of Neurological Disorders and Stroke (NINDS)100 enrolled1 locationNCT02639325
Recruiting
Phase 2Phase 3

A Study to Determine if BHV-7000 is Effective and Safe in Adults With Refractory Focal Onset Epilepsy

Focal Epilepsy
Biohaven Therapeutics Ltd.390 enrolled124 locationsNCT06132893
Recruiting
Not Applicable

AI-Based Mobile Intervention on Medication Non-Adherence and Transition

Epilepsy
University of Central Florida200 enrolled2 locationsNCT07445074
Recruiting

MEHMO Natural History and Biomarkers

ObesityEpilepsyHypogonadisms+3 more
Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)150 enrolled1 locationNCT06019182
Recruiting

Transgenerational Metabolic-Immune Biomarkers of Neurological and Neurodevelopmental Disorders

Brain TumorEpilepsyAutism Spectrum Disorder+3 more
Southwest Autism Research & Resource Center500 enrolled2 locationsNCT04322734
Recruiting
Not Applicable

Molecular Genetic Mechanisms of Infantile Epilepsies and the Impact of Genetic Diagnosis

Neonatal EpilepsyInfantile Epilepsy
Boston Children's Hospital600 enrolled1 locationNCT06701084
Recruiting

Changes in Attentional Control After a Focal Seizure.

Temporal Lobe EpilepsyFrontal Lobe EpilepsyOthers Subtypes
University Hospital, Lille100 enrolled1 locationNCT06466681
Recruiting
Not Applicable

PRIME: PReservIng Memory in Epilepsy

Mesial Temporal Lobe Epilepsy
Nitin Tandon8 enrolled2 locationsNCT05608408
Recruiting
Phase 1

Understanding Ketamine's Dissociative Effects (KD Study)

Epilepsy
Stanford University20 enrolled1 locationNCT04861051
Recruiting
Not Applicable

An Examination of Whether Infrared Light Therapy Can Reduce Stress in People With Epilepsy

Epilepsy
Cynthia Kerson80 enrolled4 locationsNCT07509177
Recruiting

PET/MRI/EEG Imaging Study in Epilepsy

Epilepsy
Massachusetts General Hospital30 enrolled1 locationNCT06974305
Recruiting
Early Phase 1

Exploratory Study of UX-GIP001 Cell Therapy in Adult Patients With Drug-Resistant Unilateral Mesial Temporal Lobe Epilepsy (MTLE)

EpilepsyMTLE
Second Affiliated Hospital, School of Medicine, Zhejiang University6 enrolled1 locationNCT07244328
Recruiting
Not Applicable

The Clinical Utility of BioEP in Diagnostic Decision Making in Epilepsy

Epilepsy
Neuronostics Ltd559 enrolled2 locationsNCT06097195
Recruiting
Phase 2

Safety and Tolerability Study of SPN-817 in Adult Patients With Treatment Resistant Epilepsy

EpilepsySeizures, Epileptic
Supernus Pharmaceuticals, Inc.60 enrolled10 locationsNCT05518578
Recruiting
Phase 1

Microelectrode Recordings From the Vagus Nerve in Awake Humans

Epilepsy
University of Minnesota60 enrolled1 locationNCT06016686
Recruiting
Phase 2Phase 3

Study to Determine if BHV-7000 is Effective and Safe in Adults With Refractory Focal Onset Epilepsy

Focal Epilepsy
Biohaven Therapeutics Ltd.390 enrolled174 locationsNCT06309966
Recruiting

Phenotypic Exploration During Sensory Stimulation in an Acoustic Chamber

EpilepsyAnxietyDepression Anxiety Disorder
Centre Hospitalier St Anne320 enrolled1 locationNCT07544563
Recruiting
Phase 4

Methylphenidate for the Treatment of Epilepsy-related Cognitive Deficits

Epilepsy
VA Office of Research and Development226 enrolled4 locationsNCT04419272
Recruiting

Patterns of Neurodevelopmental Disorders

EpilepsyAutism Spectrum DisorderNeurodevelopmental Disorders+5 more
Richard Frye1,000 enrolled1 locationNCT06213090