Epilepsy Clinical Trials

318 recruitingLast updated: June 17, 2026

There are 318 actively recruiting epilepsy clinical trials across 49 countries. Studies span Not Applicable, Phase 2, Phase 3, Phase 1, Early Phase 1, Phase 4. Top locations include Boston, Massachusetts, United States, Houston, Texas, United States, Paris, France. Updated daily from ClinicalTrials.gov.


Epilepsy Trials at a Glance

318 actively recruiting trials for epilepsy are listed on ClinicalTrialsFinder across 6 cities in 49 countries. The largest study group is Not Applicable with 133 trials, with the heaviest enrollment activity in Boston, Houston, and Paris. Lead sponsors running epilepsy studies include Xuanwu Hospital, Beijing, Hospices Civils de Lyon, and Fondation Ophtalmologique Adolphe de Rothschild.

Treatments under study

About Epilepsy Clinical Trials

Looking for clinical trials for Epilepsy? There are currently 243 studies actively recruiting participants. Clinical trials offer access to new treatments before they are widely available, and every approved therapy in use today was first tested through a clinical trial.

Below you can browse trials, sign up for alerts when new Epilepsy trials open, and view eligibility criteria for each study. Each listing includes the study phase, locations, and enrollment details.

Frequently Asked Questions

Common questions about Epilepsy clinical trials

A clinical trial is a carefully designed research study that tests new medical treatments, drugs, devices, or approaches in human volunteers. Every approved medication and treatment available today was proven safe and effective through clinical trials.

All clinical trials are reviewed and approved by Institutional Review Boards (IRBs) — independent committees that evaluate patient safety. Trials follow strict protocols, and your health is monitored closely throughout. You can withdraw at any time.

Not necessarily. Many trials compare the new treatment against the current standard of care, meaning all participants receive active treatment. When placebos are used, they are typically combined with standard treatment, not given alone. The trial description will always specify the design.

Under the Affordable Care Act, most private insurers are required to cover routine patient care costs during a clinical trial. The sponsor typically covers the investigational treatment itself. Medicare also covers routine costs for qualifying trials.

Yes. Participation is completely voluntary. You can withdraw at any time, for any reason, without it affecting your access to standard medical care.

Each trial has specific eligibility criteria — including age, diagnosis, disease stage, prior treatments, and general health. Browse the trials listed above and check their eligibility sections. You can also contact the trial site directly to discuss your situation.

Showing 120 of 318 trials

Recruiting

Noninvasive Pre-surgical Evaluation of Patients With Focal Epilepsy and Establishment of a Normative Imaging Database

Epilepsy
National Institute of Neurological Disorders and Stroke (NINDS)700 enrolled1 locationNCT02107989
Recruiting

Tumor Related Epilepsy

CancerEpilepsyBrain Neoplasm
National Institute of Neurological Disorders and Stroke (NINDS)100 enrolled1 locationNCT02639325
Recruiting
Phase 1

Investigation of Blood-Brain-Barrier Breakdown Using Manganese Magnetic Resonance Imaging in Drug-Resistant Epilepsy

Epilepsy
National Institute of Neurological Disorders and Stroke (NINDS)40 enrolled1 locationNCT02531880
Recruiting
Phase 3

Study Evaluating the Efficacy and Safety of RAP-219 in Adult Participants With Focal Seizures FOCUS-1

EpilepsyFocal EpilepsyFocal Seizure
Rapport Therapeutics Inc.333 enrolled3 locationsNCT07563881
Recruiting
Phase 1

Dose Escalation Study to Assess the Safety, Tolerability, Pharmacokinetics And Pharmacodynamics of SIF001 in Healthy Subjects and in Epilepsy Patients

EpilepsyHealthy Volunteer
Suninflam Inc88 enrolled10 locationsNCT07051629
Recruiting
Not Applicable

Bone Management in Pregnancy Outcomes in Epilepsy

EpilepsyBone HealthPregnant Woman
The Fourth Affiliated Hospital of Zhejiang University School of Medicine80 enrolled1 locationNCT07651709
Recruiting
Not Applicable

Epileptogenic Network Visualisation With Advanced MRI

Drug Resistant Epilepsy
Cliniques universitaires Saint-Luc- Université Catholique de Louvain80 enrolled1 locationNCT06059157
Recruiting
Not Applicable

Healthy Aging in People With Epilepsy Program

Epilepsy
Anny Reyes380 enrolled1 locationNCT06052605
Recruiting
Not Applicable

Subcortical Arousal in Perceptual Awareness

Epilepsy
Yale University202 enrolled8 locationsNCT06934356
Recruiting
Early Phase 1

Effect of Rose Odor Exposure on Ictal Apnea

EpilepsySudden Unexpected Death in Epilepsy
Vanderbilt University Medical Center40 enrolled1 locationNCT07116421
Recruiting
Phase 2

A Study to Investigate the Safety, Tolerability, Pharmacokinetics, and Clinical Activity of ABS-1230 in Pediatric Participants With KCNT1-related Epilepsy

KCNT1-Related Epilepsy
Actio Biosciences, Inc.45 enrolled1 locationNCT07600736
Recruiting
Not Applicable

Clinic-based and Technology-Supported Sleep Intervention for Pediatric Epilepsy

Epilepsy
National Taiwan University Hospital150 enrolled1 locationNCT06661759
Recruiting
Phase 3

Study of NRTX-1001 Neural Cell Therapy in Drug-Resistant Unilateral Mesial Temporal Lobe Epilepsy (EPIC (EPIlepsy Cell Therapy))

Mesial Temporal Lobe Epilepsy
Neurona Therapeutics88 enrolled35 locationsNCT05135091
Recruiting
Phase 3

Study Evaluating the Efficacy and Safety of RAP-219 in Adult Participants With Focal Seizures

EpilepsyFocal EpilepsyFocal Seizure
Rapport Therapeutics Inc.312 enrolled2 locationsNCT07594119
Recruiting
Not Applicable

Sleep-Sensitive Seizure Risk Assessment With Wearable EEGs

Epilepsy Intractable
Duke University35 enrolled1 locationNCT06545643
Recruiting
Not Applicable

Characterization and Analysis of Evoked Cortical Responses in Participants With Medication-intractable Epilepsy

Intractable Epilepsy
University of Michigan5 enrolled1 locationNCT07014592
Recruiting

Surgery as a Treatment for Medically Intractable Epilepsy

EpilepsyEpilepsy, Temporal LobePartial Epilepsy
National Institute of Neurological Disorders and Stroke (NINDS)300 enrolled1 locationNCT01273129
Recruiting
Not Applicable

Diagnosing Epilepsy To EffeCT Change

EpilepsyEpilepsy (Treatment Refractory)
Epiminder America, Inc.210 enrolled18 locationsNCT07110337
Recruiting

Investigating Epilepsy: Screening and Evaluation

EpilepsySeizuresEpilepsy, Temporal Lobe+1 more
National Institute of Neurological Disorders and Stroke (NINDS)1,000 enrolled1 locationNCT03478852
Recruiting

Baker Gordon Syndrome Natural History Study

Rare DiseasesSleep DisorderAutism or Autistic Traits+4 more
University of Missouri-Columbia50 enrolled1 locationNCT06399952