RecruitingNCT04593082

Obesity and Pediatric Multiple Sclerosis

Obesity as a Driver of Inflammation and Brain Volume Loss in Pediatric Multiple Sclerosis.


Sponsor

University of Virginia

Enrollment

116 participants

Start Date

Jun 3, 2021

Study Type

OBSERVATIONAL

Conditions

Summary

Obesity is one possible contributor to severity of multiple sclerosis and progression of the disease. We already know that obesity is a risk determinant for acquiring MS, yet the impact of obesity on pediatric MS disease expression and course is unknown. This study will evaluate the relationship between obesity, obesity-derived inflammatory mediators, and imaging metrics of MS severity in children. Understanding how childhood obesity contributes to MS severity/progression may yield fundamental insights into disease pathobiology - which may thereby lead to effective strategies for halting its progression in its earliest stages.


Eligibility

Min Age: 10 YearsMax Age: 20 Years

Plain Language Summary

Simplified for easier understanding

This study examines whether being overweight or obese affects how multiple sclerosis (MS) progresses in children and young adults. Researchers will compare young people with MS to healthy children matched by age, sex, and weight to understand the connection between body weight and MS disease activity. **You may be eligible if...** - You are between 10 and 20 years old - You have been diagnosed with relapsing-remitting MS within the past 3 years - OR you are a healthy child or young adult willing to serve as a comparison participant **You may NOT be eligible if...** - You have a progressive form of MS - You have another active immune system disease - You have had steroid treatment within 30 days of enrollment - You have a condition affecting the brain's white matter other than MS - You have MOG antibodies (suggesting a different diagnosis) Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Locations(2)

Children's Hospital of Philadelphia

Philadelphia, Pennsylvania, United States

University of Virginia

Charlottesville, Virginia, United States

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NCT04593082


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