RecruitingNot ApplicableNCT04600973

Improving Implementation of Evidence-based Approaches and Surveillance to Prevent Bacterial Transmission and Infection

The BASIC Trial: Improving Implementation of Evidence-based Approaches and Surveillance to Prevent Bacterial Transmission and Infection

Sponsor

Trustees of Dartmouth College

Enrollment

6,000 participants

Start Date

Jul 1, 2021

Study Type

INTERVENTIONAL

Conditions

Infection

Summary

Surgical site infections (SSIs) are associated with increased patient morbidity, mortality, and healthcare costs. ESKAPE (Enterococcus, S. aureus, Klebsiella, Acinetobacter, Pseudomonas, and Enterobacter spp.) pathogens are particularly pathogenic because they have increased capacity to acquire resistance and virulence traits. The investigators have proven that a multifaceted program involving improved basic perioperative preventive measures can generate substantial reductions in S. aureus transmission and significant reductions in SSIs (88% reduction as compared to usual care). In this study, the investigators aim to examine the relative effectiveness of each component of this program in controlling ESKAPE transmission and reducing SSIs and to identify an optimal implementation strategy for national dissemination. Randomization occurs at the site level, and sites adopt preventative programs. This work will improve perioperative patient safety for the 51 million patients who undergo surgery each year.

Eligibility

Min Age: 18 Years

Plain Language Summary

Simplified for easier understanding

This trial is testing improved methods to prevent bacterial infections after orthopedic surgeries — such as joint replacements or spine operations — by using better skin preparation and monitoring practices. You may be eligible (as a patient) if: you are scheduled for an elective orthopedic joint or spine surgery at a participating hospital. You may NOT be eligible if: your procedure does not require anesthesia or an IV line; there is no skin incision; you have an allergy to chlorhexidine, povidone iodine, or isopropyl alcohol; or your overall health risk is very high (ASA class above 5). Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

BEHAVIORALTechnical assistance or team-based coaching

Main comparison in delivering peri-operative preventive strategies against transmission and infection is one on one technical assistance or team-based coaching.