RecruitingNCT04602338

Diagnosis and OutcoMes evaluAtIoN of Multicenter Patients With HFpEF Using Multimodality Imaging

Multimodality Imaging (Cardiovascular Magnetic Resonance Imaging, Echocardiography, and Nuclear Medicine Imaging) in the Screening, Diagnosis and Risk Stratification of Heart Failure With Preserved Ejection Fraction- a Multicenter Study.

Sponsor

Chinese Academy of Medical Sciences, Fuwai Hospital

Enrollment

1,000 participants

Start Date

Nov 1, 2020

Study Type

OBSERVATIONAL

Conditions

Multicenter Study Heart Failure, Diastolic

Summary

The incidence of Heart failure with preserved ejection fraction (HFpEF) in Heart failure patients increases rapidly. However, the current clinical awareness is insufficient, and the cardiac structural and functional injury are not well understood. It is difficult to recognize the subclinical changes of the cardiac in the early stage with conventional imaging techniques, and it is common to ignore the existence of the clinical alterations. This study aimed to investigate the cardiac features, early diagnosis and risk factors of HFpEF patients, based on the multi-modality (Magnetic resonance imaging- nuclear medicine imaging- echocardiography) imaging and multicenter study, combined with large data and artificial intelligence. This study will provide deep insights into the HFpEF in multicenter population.

Eligibility

Plain Language Summary

Simplified for easier understanding

This study follows patients with a type of heart failure where the heart pumps normally but is too stiff — called HFpEF (heart failure with preserved ejection fraction) — and uses multiple types of imaging (ultrasound, MRI, CT) to better understand, diagnose, and predict outcomes in this condition. **You may be eligible if...** - You have symptoms of heart failure - Your heart pumping function is normal or near-normal (ejection fraction of 50% or higher) - Your blood levels of a heart stress marker (NT-proBNP or BNP) are elevated - You have evidence of heart stiffness or enlargement on cardiac imaging **You may NOT be eligible if...** - You have a specific type of heart muscle disease (like hypertrophic or restrictive cardiomyopathy) - Your heart failure is caused by a heart attack or blocked arteries - You have severe heart rhythm problems or valve disease - You have constrictive pericardial disease - You refuse to participate Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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