RecruitingNCT04603404

Multimodality Imaging in the Screening, Diagnosis and Risk StratifictiON of HFpEF

Multimodality Imaging (Cardiovascular Magnetic Resonance Imaging, Echocardiography, and Nuclear Medicine Imaging) in the Screening, Diagnosis and Risk Stratification of Heart Failure With Preserved Ejection Fraction (HFpEF).

Sponsor

Chinese Academy of Medical Sciences, Fuwai Hospital

Enrollment

430 participants

Start Date

Jan 1, 2019

Study Type

OBSERVATIONAL

Conditions

Heart Failure, Diastolic

Summary

The incidence of Heart failure with preserved ejection fraction (HFpEF) in Heart failure patients increases rapidly. However, the current clinical awareness is insufficient, and the cardiac structural and functional injury are not well understood. It is difficult to recognize the subclinical changes of the cardiac in the early stage with conventional imaging techniques, and it is common to ignore the existence of the clinical alterations. This study aimed to investigate the cardiac features, early diagnosis and risk factors of HFpEF patients, based on the multi-modal (Magnetic resonance imaging- nuclear medicine imaging- echocardiography) imaging, combined with large data and artificial intelligence. This study will provide deep insights into the HFpEF derived from different causes.

Eligibility

Plain Language Summary

Simplified for easier understanding

This study uses multiple types of heart imaging — including ultrasound, MRI, and CT — to improve how doctors screen for, diagnose, and assess the risk of complications in HFpEF, a type of heart failure where the heart is too stiff despite pumping normally. Researchers want to identify better markers for predicting who will do worse. **You may be eligible if...** - You have symptoms of heart failure - Your heart pumping function is normal or near-normal (ejection fraction of 50% or higher) - Blood markers of heart stress (NT-proBNP or BNP) are elevated - Imaging shows your heart structure or function is abnormal (thickened walls, enlarged upper chamber, or reduced relaxation) **You may NOT be eligible if...** - You have a specific uncommon cardiomyopathy type (hypertrophic or restrictive) - Your heart failure is from a heart attack, blocked arteries, or acute coronary syndrome - You have severe arrhythmias or valve disease - You have constrictive pericardial disease - You refuse to participate Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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