RecruitingNCT04616300

Exercise and Cognitive (Brain) Function in Breast Cancer Patients Getting Chemotherapy After Breast Surgery

Cardiorespiratory Fitness, Inflammatory Biomarkers, and Cognitive Function Patterns During Treatment for Breast Cancer: a Prospective Cohort Study

Sponsor

University of Toronto

Enrollment

50 participants

Start Date

Dec 12, 2019

Study Type

OBSERVATIONAL

Conditions

Breast Cancer

Summary

This study will primarily identify longitudinal associations between cardiorespiratory fitness (CRF) and cognitive function pre- (baseline) to post-chemotherapy (\~3 months). This will be a prospective study of 50 BCS. We hypothesize that breast cancer patients undergoing chemotherapy who have higher levels of CRF at baseline will have significantly improved measures of attention, executive function, and memory post-chemotherapy. In addition, the exploratory aims will examine the longitudinal associations between physical activity (PA) and cognitive function from pre- to post-chemotherapy and explore the associations between inflammatory and non-inflammatory biomarkers and CRF with cognitive function.

Eligibility

Sex: FEMALEMin Age: 18 YearsMax Age: 65 Years

Plain Language Summary

Simplified for easier understanding

This study is examining whether an exercise program during chemotherapy can help preserve brain function (memory, concentration) in women with early-stage breast cancer. "Chemo brain" — difficulty thinking clearly during and after chemotherapy — is a common concern that this study aims to address. **You may be eligible if...** - You are between 18 and 65 years old - You have stage I–III breast cancer confirmed by biopsy - You have not yet started chemotherapy (or completed less than 1 cycle) - You do not have a diagnosed major cognitive disorder or serious uncontrolled medical condition **You may NOT be eligible if...** - You received neoadjuvant chemotherapy before surgery and are now scheduled for more chemotherapy - You are receiving radiation therapy at the same time as chemotherapy Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Locations(1)

Sunnybrook Health Sciences Centre-Odette Cancer Centre

Toronto, Ontario, Canada

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NCT04616300

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