Concomitant Renal and Urinary Bladder Allograft Transplantation

This study is testing whether it is safe and feasible to transplant both a kidney and a bladder at the same time for patients whose kidney disease is caused by a severely damaged or dysfunctional bladder. This is a highly specialized procedure being evaluated at Mayo Clinic. **You may be eligible if...** - You are between 1 and 60 years old - Your kidney disease is caused by a neurogenic bladder or other bladder disorder - Your bladder is considered "hostile" — meaning it stores urine at dangerously high pressures or causes kidney damage - If also needing a kidney transplant: your kidney function is very poor (GFR ≤ 20 mL/min) or you are on dialysis - You have been approved by the Mayo Clinic transplant team - You are able to learn bladder self-catheterization (or already do it) - You have no cancer history in the last 5 years (except minor skin cancer) **You may NOT be eligible if...** - You are pregnant or breastfeeding, or planning pregnancy during the study - You have certain heart, lung, liver, or kidney conditions that make surgery too risky - You have had or are at high risk for cancer - You have uncontrolled psychiatric illness or serious infection Talk to your doctor to see if this trial is right for you.