Bleeding Reduction in Acute and Chronic Kidney Patients Having Surgery (BRACKETS) Pilot Trial

This pilot study, called BRACKETS, tests whether the blood-clot-reducing drug tranexamic acid (TXA) can safely reduce bleeding in people with significant kidney disease who are having non-cardiac surgery. **You may be eligible if...** - You are 18 or older - You have severely reduced kidney function (eGFR below 25 mL/min) OR you have been on dialysis within the past 7 days - You are scheduled for non-cardiac surgery (planned or urgent) - You are expected to stay in the hospital overnight after surgery **You may NOT be eligible if...** - You are having heart surgery or brain surgery - You are having surgery to create or revise an arteriovenous (AV) access for dialysis - You have a history of blood clots in veins or arteries - You have active bleeding or a known bleeding disorder - (Other specific exclusions may apply per the study protocol) Talk to your doctor to see if this trial is right for you.