Effect of Probiotics on the Periodontal Status of Orthodontic Patients

This study is investigating whether taking a probiotic supplement can improve gum (periodontal) health in young patients who wear fixed orthodontic appliances (braces). When braces are placed, they make it harder to clean teeth properly, which allows bacteria to build up and can cause gum inflammation. Probiotics are beneficial bacteria that may help restore a healthier balance of bacteria in the mouth and reduce gum disease. Adolescents aged 12 to 16 who are starting orthodontic treatment will be randomly assigned to receive either a specific probiotic (Gum PerioBalance) or a control, and their gum health will be monitored over time. This study will help determine whether adding probiotics to an orthodontic patient's routine can meaningfully improve oral health outcomes. You may be eligible if: - You are between 12 and 16 years old - You are in good general health - You have fixed orthodontic appliances (braces) - You and your parents have given consent to participate - You are covered by social security You may NOT be eligible if: - You have used another probiotic or antiseptic mouthwash in the past month - You have had antibiotic therapy in the past month - You have conditions or medications that could affect your mouth (e.g., diabetes, pregnancy, epilepsy medications, tobacco use) - You have untreated cavities, active periodontitis, or other urgent oral health needs - You are allergic to any ingredients in the Gum PerioBalance probiotic - You are immunosuppressed or require prophylactic antibiotics before dental care Talk to your doctor to see if this trial is right for you.