RecruitingNCT04634643
Pathogenesis of Pediatric Nonalcoholic Fatty Liver Disease (NAFLD)
Pathophysiologic Mechanisms Leading to Intrahepatic Fat Accumulation in Obese Youth
Sponsor
Yale University
Enrollment
260 participants
Start Date
Jun 28, 2021
Study Type
OBSERVATIONAL
Conditions
Summary
The main aim of the study is to discover the mechanisms underlying the pathophysiology of NAFLD in obese youth.
Eligibility
Min Age: 12 YearsMax Age: 18 Years
Inclusion Criteria3
- Good general health, taking no medication on a chronic basis;
- age 12 to 18 years, in puberty (girls and boys: Tanner stage II-V);
- BMI >85th for obese cohort;
Exclusion Criteria6
- Baseline creatinine >1.0 mg; pregnancy;
- the presence of endocrinopathies (e.g. Cushing syndrome);
- cardiac or pulmonary or other significant chronic illness;
- adolescents with a psychiatric disorder or with substance abuse;
- monogenic obesity syndromes;
- use of drugs affecting intrahepatic fat content (e.g.; liraglutide, fish oil, etc.).
Interested in this trial?
Get notified about updates and connect with the research team.
Interventions
OTHERUsual diet and physical activity
Patients will be followed up to assess the effect of the usual diet and physical activity on development of NAFLD
Locations(1)
View Full Details on ClinicalTrials.gov
For the most up-to-date information, visit the official listing.
NCT04634643
Related Trials
Non-alcoholic Fatty Liver Disease in Low Birth Weight Individuals
NCT058428502 locations
Bicalutamide Therapy in Young Women With NAFLD and PCOS
NCT059793891 location
Androgens and NAFLD Longitudinal Cohort Study
NCT061242612 locations
Effects of Two Different Exercise Programs and Diet in Obese Subjects With NAFLD
NCT061868691 location
Target of Suv420h1/2 in Hepatocytes
NCT063326771 location