NAFLD Clinical Trials

41 recruiting

NAFLD Trials at a Glance

50 actively recruiting trials for nafld are listed on ClinicalTrialsFinder across 6 cities in 23 countries. The largest study group is Not Applicable with 27 trials, with the heaviest enrollment activity in Paris, Angers, and New Haven. Lead sponsors running nafld studies include Azienda Ospedaliera Specializzata in Gastroenterologia Saverio de Bellis, Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico, and Yale University.

Browse nafld trials by phase

Treatments under study

About NAFLD Clinical Trials

Looking for clinical trials for NAFLD? There are currently 41 studies actively recruiting participants. Clinical trials offer access to new treatments before they are widely available, and every approved therapy in use today was first tested through a clinical trial.

Below you can browse trials, sign up for alerts when new NAFLD trials open, and view eligibility criteria for each study. Each listing includes the study phase, locations, and enrollment details.

Frequently Asked Questions

Common questions about NAFLD clinical trials

A clinical trial is a carefully designed research study that tests new medical treatments, drugs, devices, or approaches in human volunteers. Every approved medication and treatment available today was proven safe and effective through clinical trials.

All clinical trials are reviewed and approved by Institutional Review Boards (IRBs) — independent committees that evaluate patient safety. Trials follow strict protocols, and your health is monitored closely throughout. You can withdraw at any time.

Not necessarily. Many trials compare the new treatment against the current standard of care, meaning all participants receive active treatment. When placebos are used, they are typically combined with standard treatment, not given alone. The trial description will always specify the design.

Under the Affordable Care Act, most private insurers are required to cover routine patient care costs during a clinical trial. The sponsor typically covers the investigational treatment itself. Medicare also covers routine costs for qualifying trials.

Yes. Participation is completely voluntary. You can withdraw at any time, for any reason, without it affecting your access to standard medical care.

Each trial has specific eligibility criteria — including age, diagnosis, disease stage, prior treatments, and general health. Browse the trials listed above and check their eligibility sections. You can also contact the trial site directly to discuss your situation.

Showing 120 of 50 trials

Recruiting
Not Applicable

Non-alcoholic Fatty Liver Disease in Low Birth Weight Individuals

NAFLD
Steno Diabetes Center Copenhagen8 enrolled2 locationsNCT05842850
Recruiting
Phase 1

Bicalutamide Therapy in Young Women With NAFLD and PCOS

PCOSNAFLD
University of California, San Francisco50 enrolled1 locationNCT05979389
Recruiting

Single-cell Multiomics and Spatiotemporal Omics Analyze the Mechanism of Liver Degenerative Disease

Liver NeoplasmLiver FibrosisHBV Infection+1 more
Nanfang Hospital, Southern Medical University240 enrolled1 locationNCT07265544
Recruiting

Androgens and NAFLD Longitudinal Cohort Study

PCOSNAFLDNASH
University of California, San Francisco150 enrolled2 locationsNCT06124261
Recruiting
Not Applicable

Effects of Two Different Exercise Programs and Diet in Obese Subjects With NAFLD

ObesityNAFLD
Azienda Ospedaliera Specializzata in Gastroenterologia Saverio de Bellis90 enrolled1 locationNCT06186869
Recruiting
Not Applicable

Target of Suv420h1/2 in Hepatocytes

NAFLD
Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico260 enrolled1 locationNCT06332677
Recruiting
Not Applicable

Development of a Quantifiable Ultrasound Biomarker for Hepatic Steatosis

NAFLD - Non-Alcoholic Fatty Liver DiseaseMASLD - Metabolic Dysfunction-Associated Steatotic Liver Disease
ContextVision AB110 enrolled1 locationNCT07270601
Recruiting
Not Applicable

The Liver BIoBank Lombardia of Fatty Liver

Cardiovascular DiseasesNAFLDPrecision Medicine
Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico2,500 enrolled1 locationNCT06566105
Recruiting
Not Applicable

Human Liver ORganoids as a Model to Study the Development of Non-Alcoholic SteatOhepatitis (NASH)

NAFLD
Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico60 enrolled1 locationNCT06856252
Recruiting
Not Applicable

Comparison of Two sTRAtegies For the Non-Invasive Diagnosis of advanCed Liver Fibrosis in NAFLD

NAFLD
University Hospital, Angers1,045 enrolled20 locationsNCT04681573
Recruiting
Not Applicable

NAFLD Clinical Care Pathway

MASLDNAFLD
VA Office of Research and Development32 enrolled1 locationNCT06671886
Recruiting
Phase 2

Digoxin In NASH (CODIN)

MASH - Metabolic Dysfunction-Associated SteatohepatitisNAFLDNASH
Yale University144 enrolled2 locationsNCT06588699
Recruiting
Not Applicable

NASH AMPK Exercise Dosing (AMPED) Trial

NAFLD
Milton S. Hershey Medical Center45 enrolled1 locationNCT04987879
Recruiting
Not Applicable

Exploratory Study of MRI Biomarkers of NASH

Non-alcoholic Fatty Liver Disease NAFLD
University Hospital, Angers60 enrolled1 locationNCT06626074
Recruiting
Phase 3

Effect of Amino Acids on Hepatic Fat Content in Adolescents (AMINOS Study)

NAFLDHepatic SteatosisAdolescent Obesity
University of Colorado, Denver55 enrolled1 locationNCT05935826
Recruiting
Not Applicable

Evaluation of a New Ultrasound System for the Non-invasive Assessment of Liver Steatosis in MASLD/MASH Patients

MASLDMASH - Metabolic Dysfunction-Associated SteatohepatitisNAFLD+4 more
E-Scopics120 enrolled3 locationsNCT06661655
Recruiting
Not Applicable

The Impact of Pectin Supplementation on Systematic Inflammation Pathway, Gut Microbiome, and Metabolic Health in Patients With Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD)

MASLDNAFLD (Nonalcoholic Fatty Liver Disease)Metabolic Dysfunction-Associated Steatotic Liver Disease+4 more
University of Nottingham45 enrolled3 locationsNCT07093346
Recruiting
Not Applicable

Prevalence of NAFLD in T1DM Patients

Type 1 DiabetesNAFLDFatty Liver, Nonalcoholic
Ziekenhuis Oost-Limburg138 enrolled1 locationNCT06445361
Recruiting
Not Applicable

Gepaktiv vs UDCA and Ademetionine in MAFLD With Hepatomegaly

Fatty Liver DiseaseHepatomegalyFatty Liver+5 more
Phenomen Pharma90 enrolled1 locationNCT07068191
Recruiting

Digital Early Warning System for Acute Lung Injury in Liver Surgery

MASLD/MASH (Metabolic Dysfunction-Associated Steatotic Liver Disease / Metabolic Dysfunction-Associated Steatohepatitis)Acute Lung Injury(ALI)Liver Cirrhosis+4 more
Beijing Tsinghua Chang Gung Hospital4,000 enrolled1 locationNCT07070362