Uncovering a Novel Therapeutic Target to Reduce Dementia Risk in Parkinson's Disease

This study is investigating a new treatment approach to reduce the risk of developing dementia in people with Parkinson's disease. Researchers are looking at whether a medication called levetiracetam (typically used for epilepsy) can target a specific brain mechanism linked to memory decline in Parkinson's, using brain MRI scans to track changes. **You may be eligible if...** - You have Parkinson's disease — with or without mild memory problems - You are able to have an MRI scan - Healthy volunteers without Parkinson's or memory problems are also eligible for comparison **You may NOT be eligible if...** - You already have full dementia - You have a metal implant or other reason you cannot have an MRI - You have bipolar disorder, schizophrenia, or major depression - You have had suicidal thoughts - You have severe kidney problems - You are sensitive to levetiracetam or take anticonvulsant medications - You are a woman of childbearing potential - You have significant abnormalities in B12 or thyroid levels Talk to your doctor to see if this trial is right for you.