Mild Cognitive Impairment Clinical Trials

115 recruiting

Frequently Asked Questions

Common questions about Mild Cognitive Impairment clinical trials

A clinical trial is a carefully designed research study that tests new medical treatments, drugs, devices, or approaches in human volunteers. Every approved medication and treatment available today was proven safe and effective through clinical trials.

All clinical trials are reviewed and approved by Institutional Review Boards (IRBs) — independent committees that evaluate patient safety. Trials follow strict protocols, and your health is monitored closely throughout. You can withdraw at any time.

Not necessarily. Many trials compare the new treatment against the current standard of care, meaning all participants receive active treatment. When placebos are used, they are typically combined with standard treatment, not given alone. The trial description will always specify the design.

Under the Affordable Care Act, most private insurers are required to cover routine patient care costs during a clinical trial. The sponsor typically covers the investigational treatment itself. Medicare also covers routine costs for qualifying trials.

Yes. Participation is completely voluntary. You can withdraw at any time, for any reason, without it affecting your access to standard medical care.

Each trial has specific eligibility criteria — including age, diagnosis, disease stage, prior treatments, and general health. Browse the trials listed above and check their eligibility sections. You can also contact the trial site directly to discuss your situation.

Showing 120 of 152 trials

Recruiting
Phase 1

PET Imaging of Phosphodiesterase-4 (PDE4) in Volunteers With Alzheimer Disease (AD) or Mild Cognitive Impairment (MCI)

HealthyMild Cognitive ImpairmentAlzheimer s Disease
National Institute of Mental Health (NIMH)90 enrolled1 locationNCT07169630
Recruiting
Phase 2

Novel Augmentation of DAOIB and Antioxidant for Early Dementia

Alzheimer DiseaseMild Cognitive Impairment
Chang Gung Memorial Hospital80 enrolled1 locationNCT06467539
Recruiting
Early Phase 1

Psilocybin for Depression in People With Mild Cognitive Impairment or Early Alzheimer's Disease

DepressionDepressive SymptomsAlzheimer Disease+1 more
Johns Hopkins University20 enrolled1 locationNCT04123314
Recruiting

Validating the On-line Creyos Cognitive Assessment Platform in Older Adults With Major Depressive Disorder or Mild Cognitive Impairment

Mild Cognitive Impairment (MCI)Major Depressive Disorder, RemittedHealthy Controls Group - Age and Sex-matched
Centre for Addiction and Mental Health150 enrolled3 locationsNCT06780917
Recruiting

Digital Accessible Remote Olfactory Mediated Health Assessments for Preclinical AD

Mild Cognitive ImpairmentHealthy AgingSubjective Cognitive Concerns+1 more
Massachusetts General Hospital250 enrolled1 locationNCT05881239
Recruiting
Phase 1

TREAD: Time Restricted Eating Intervention for Alzheimer's Disease

Alzheimer DiseaseMild Cognitive ImpairmentAlzheimer s Disease
University of California, San Diego60 enrolled1 locationNCT06548191
Recruiting
Not Applicable

Anxiety Sensitivity Treatment to Reduce Anxiety in Alzheimer's

DementiaAnxietyAlzheimer Disease+1 more
Florida State University388 enrolled3 locationsNCT05748613
Recruiting
Phase 3

GLP-1/GCG Dual Agonist in Type 2 Diabetes With Early Dementia (LIGHT-COG Study)

Type 2 DiabetesDementia, MildMild Cognitive Impairment
The Affiliated Nanjing Drum Tower Hospital of Nanjing University Medical School420 enrolled8 locationsNCT07083154
Recruiting
Not Applicable

Locomotion Adaptation Deficits in Older Adults With Mild Cognitive Impairment and Alzheimers Disease

Mild Cognitive ImpairmentAlzheimers Disease
Emory University10 enrolled1 locationNCT06484244
Recruiting
Not Applicable

Effect of Striatal Temporal Interference Stimulation on Language Processing in Neurodegenerative Diseases

Mild Cognitive Impairment (MCI) AmnesticLewy Body Disease With Mild Cognitive ImpairmentParkinson's Disease With Mild Cognitive Impairment
Masaryk University70 enrolled1 locationNCT07449117
Recruiting
Early Phase 1

Effects of Nicotinamide Riboside on Bioenergetics and Oxidative Stress in Mild Cognitive Impairment/Alzheimer's Dementia

Mild Cognitive ImpairmentMild Alzheimer Disease
Mclean Hospital50 enrolled1 locationNCT04430517
Recruiting
Not Applicable

Study to Investigate Vagus Nerve Stimulation to Augment Executive Function in Healthy and Cognitively Impaired Populations

Mild Cognitive Impairment (MCI)Parkinsons Disease (PD)Healthy Adult
University of Colorado, Denver80 enrolled1 locationNCT07424365
Recruiting
Early Phase 1

Transcranial Magnetic Stimulation Treatment for Alzheimer's Disease

Alzheimer DiseaseMild Cognitive ImpairmentLogopenic Progressive Aphasia+1 more
Massachusetts General Hospital30 enrolled1 locationNCT06538311
Recruiting

Longitudinal Early-onset Alzheimer's Disease Study Protocol

Early-Onset Alzheimer DiseaseAlzheimer DiseaseMild Cognitive Impairment
Indiana University850 enrolled23 locationsNCT03507257
Recruiting
Phase 1

PET Imaging of Cyclooxygenases in Neurodegenerative Brain Disease

DementiaALSMild Cognitive Impairment+2 more
National Institute of Mental Health (NIMH)184 enrolled1 locationNCT04396873
Recruiting
Phase 3

Evaluate the Use of [18F]-APN-1607 PET in Subjects With AD-related Cognitive Impairment and Subjects With Normal Cognitive Function

Subjects With Mild Cognitive Impairment (MCI) of AD, Alzheimer's Disease (AD) Dementia
JYAMS PET Research & Development Limited316 enrolled2 locationsNCT07422857
Recruiting

VR Pupillometry in Cognitive Impairment

DementiaMajor Depressive Disorder (MDD)Mild Cognitive Impairment+1 more
Max-Planck-Institute of Psychiatry140 enrolled1 locationNCT07402356
Recruiting
Not Applicable

Validation of a Digital Intervention to Rehabilitate Cognitive Resources

Mild Cognitive Impairment (MCI)Dementia Alzheimer TypeSubjective Memory Complaint
Fondazione Don Carlo Gnocchi Onlus102 enrolled1 locationNCT07064226
Recruiting

Development of a Database to Investigate Digital and Blood-Based Biomarkers and Their Relationship to Tau and Amyloid PET Imaging in Older Participants Who Are Cognitively Normal (CN), Have Mild Cognitive Impairment (MCI), or Have Mild-to-Moderate AD Dementia

Memory DisordersMild Cognitive ImpairmentMemory Impairment+3 more
GAP Innovations, PBC1,200 enrolled25 locationsNCT06584357
Recruiting
Not Applicable

Feasibility and Adherence to a Technology-assisted Home-based Strength Training Program in Adults With Type 2 Diabetes Mellitus and Mild Cognitive Impairment

Age-related Cognitive DeclineMild Cognitive ImpairmentType2diabetes
The University of Texas Medical Branch, Galveston20 enrolled1 locationNCT07416799