Mild Cognitive Impairment Clinical Trials

221 recruiting

Mild Cognitive Impairment Trials at a Glance

266 actively recruiting trials for mild cognitive impairment are listed on ClinicalTrialsFinder across 6 cities in 33 countries. The largest study group is Not Applicable with 153 trials, with the heaviest enrollment activity in Toronto, Boston, and New York. Lead sponsors running mild cognitive impairment studies include Johns Hopkins University, Massachusetts General Hospital, and The University of Hong Kong.

Browse mild cognitive impairment trials by phase

Treatments under study

About Mild Cognitive Impairment Clinical Trials

Looking for clinical trials for Mild Cognitive Impairment? There are currently 221 studies actively recruiting participants. Clinical trials offer access to new treatments before they are widely available, and every approved therapy in use today was first tested through a clinical trial.

Below you can browse trials, sign up for alerts when new Mild Cognitive Impairment trials open, and view eligibility criteria for each study. Each listing includes the study phase, locations, and enrollment details.

Frequently Asked Questions

Common questions about Mild Cognitive Impairment clinical trials

A clinical trial is a carefully designed research study that tests new medical treatments, drugs, devices, or approaches in human volunteers. Every approved medication and treatment available today was proven safe and effective through clinical trials.

All clinical trials are reviewed and approved by Institutional Review Boards (IRBs) — independent committees that evaluate patient safety. Trials follow strict protocols, and your health is monitored closely throughout. You can withdraw at any time.

Not necessarily. Many trials compare the new treatment against the current standard of care, meaning all participants receive active treatment. When placebos are used, they are typically combined with standard treatment, not given alone. The trial description will always specify the design.

Under the Affordable Care Act, most private insurers are required to cover routine patient care costs during a clinical trial. The sponsor typically covers the investigational treatment itself. Medicare also covers routine costs for qualifying trials.

Yes. Participation is completely voluntary. You can withdraw at any time, for any reason, without it affecting your access to standard medical care.

Each trial has specific eligibility criteria — including age, diagnosis, disease stage, prior treatments, and general health. Browse the trials listed above and check their eligibility sections. You can also contact the trial site directly to discuss your situation.

Showing 120 of 266 trials

Recruiting
Phase 1

PET Imaging of Phosphodiesterase-4 (PDE4) in Volunteers With Alzheimer Disease (AD) or Mild Cognitive Impairment (MCI)

HealthyMild Cognitive ImpairmentAlzheimer s Disease
National Institute of Mental Health (NIMH)90 enrolled1 locationNCT07169630
Recruiting
Not Applicable

Characterizing Variability in Hearing Aid Outcomes in Among Older Adults With Alzheimer's Dementia

Dementia of Alzheimer TypeHearing Loss, SensorineuralAmnestic Mild Cognitive Impairment
Northwestern University20 enrolled2 locationsNCT04240561
Recruiting
Not Applicable

Non-invasive Stimulation of Deep Brain Structures to Modulate Working Memory

Mild Cognitive Impairment (MCI)Older Adults (60 - 85 Years Old)
Masaryk University70 enrolled1 locationNCT07560904
Recruiting
Not Applicable

Personalized Digital Training for COGnitive FITness in Mild Cognitive Impairment

Mild Cognitive Impairment (MCI)Subjective Cognitive Decline (SCD)
Giovanna Zamboni100 enrolled2 locationsNCT07286448
Recruiting
Not Applicable

Closed-Loop Brain Stimulation as a Potential Intervention for Cognitive Decline

Mild Cognitive Impairment
University of Texas at Austin180 enrolled1 locationNCT05907343
Recruiting
Not Applicable

tDCS on Parkinson's Disease Cognition

Parkinson DiseaseMild Cognitive Impairment
University of Manitoba36 enrolled1 locationNCT03025334
Recruiting
Not Applicable

Auditory Sleep Stimulation or Sham in People With Parkinson Disease Mild Cognitive Impairment During Cognitive Training

Mild Cognitive ImpairmentParkinson's Disease
University of Zurich50 enrolled1 locationNCT07441915
Recruiting

Genetic Studies of Early-onset Dementia

Mild Cognitive Impairment (MCI)Alzheimer Dementia (AD)Memory Loss+1 more
Columbia University1,000 enrolled1 locationNCT04906863
Recruiting

Identifying Cerebral Hemodynamic Patterns in Mood Disorders and Mild Cognitive Impairment: A Functional Near-Infrared Spectroscopy (fNIRS) Study

Major Depressive DisorderBipolar DisorderMild Cognitive Impairment
Mayo Clinic200 enrolled1 locationNCT06897670
Recruiting
Not Applicable

IHT for Mild Cognitive Impairment

Mild Cognitive ImpairmentMemory Impairment
University of North Texas Health Science Center66 enrolled1 locationNCT05495087
Recruiting
Not Applicable

A Multifocal tDCS-EEG Protocol for Improving Symptoms of Mild Cognitive Impairment and Early Dementia

DementiaAlzheimer DiseaseAlzheimer Disease, Early Onset+1 more
University of Campania Luigi Vanvitelli50 enrolled1 locationNCT06668610
Recruiting
Phase 1Phase 2

rTMS to Improve Cognition in Parkinson's

Mild Cognitive ImpairmentParkinson's Disease
VA Office of Research and Development56 enrolled2 locationsNCT03836950
Recruiting

InRAD Observational Study

Mild Cognitive Impairment (MCI)Alzheimer's Disease(AD)Subjective Cognitive Decline (SCD)+1 more
Stichting International Registry for Alzheimer's Disease and other Dementias Foundation50,000 enrolled1 locationNCT07213700
Recruiting
Phase 1Phase 2

Biomarker-based Trial of NPC-1 for Alzheimer's Pathology

Alzheimer DiseaseMild Cognitive Impairment (MCI)Subjective Cognitive Complaints (SCCs)
Massachusetts General Hospital40 enrolled1 locationNCT07236190
Recruiting

Development of a Database to Investigate Digital and Blood-Based Biomarkers and Their Relationship to Tau and Amyloid PET Imaging in Older Participants Who Are Cognitively Normal (CN), Have Mild Cognitive Impairment (MCI), or Have Mild-to-Moderate AD Dementia

Mild Cognitive Impairment
GAP Innovations, PBC1,200 enrolled26 locationsNCT06584357
Recruiting
Not Applicable

Low Intensity Focused Ultrasound for Mild Cognitive Impairment and Mild Alzheimer's Disease

Deep Brain StimulationMild Cognitive ImpairmentMild Alzheimer's Disease+1 more
University of California, Los Angeles144 enrolled1 locationNCT05417555
Recruiting
Not Applicable

rTMS for Apathy Clinical Trial

DementiaAlzheimer DiseaseMild Cognitive Impairment+3 more
Sunnybrook Health Sciences Centre10 enrolled1 locationNCT05561205
Recruiting
Not Applicable

Exercise as a Primer for Brain Stimulation in Vascular Cognitive Impairment No Dementia (VCIND)

Mild Cognitive ImpairmentVascular Cognitive Impairment
Sunnybrook Health Sciences Centre64 enrolled1 locationNCT05079464
Recruiting
Not Applicable

Brain Stimulation and Cognitive Training for MCI

Mild Neurocognitive DisorderCognitive DysfunctionMild Cognitive Impairment (MCI)+2 more
Medical University of South Carolina50 enrolled1 locationNCT07526740
Recruiting
Not Applicable

Feasibility Study of 'SuperBrain BOOM' for Mild Cognitive Impairment Patients

Mild Cognitive Impairment (MCI)
Ajou University School of Medicine45 enrolled4 locationsNCT07101380