Cord Blood Transplant in Children and Young Adults With Blood Cancers and Non-malignant Disorders
Cord Blood Transplantation in Children and Young Adults With Hematologic Malignancies and Non-malignant Disorders
Memorial Sloan Kettering Cancer Center
31 participants
Nov 20, 2020
INTERVENTIONAL
Conditions
Summary
This is a single-arm study to investigate 1-year treatment related mortality (TRM) in patients with life threatening non-malignant and malignant hematologic disorders who do not have a matched related donor for allogeneic transplantation.
Eligibility
Plain Language Summary
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Interventions
Clofarabine
Fludarabine
Busulfan per PK
GVHD prophylaxis will consist of cyclosporine-A (CSA) and mycophenolate mofetil (MMF) starting day -3.
GVHD prophylaxis will consist of cyclosporine-A (CSA) and mycophenolate mofetil (MMF) starting day -3.
The CB graft will be infused on day 0 per standard practice
Locations(1)
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NCT04644016