HLH Clinical Trials

3 recruiting

HLH Trials at a Glance

8 actively recruiting trials for hlh are listed on ClinicalTrialsFinder across 6 cities in 10 countries. The largest study group is Phase 2 with 4 trials, with the heaviest enrollment activity in Philadelphia, New York, and Houston. Lead sponsors running hlh studies include Beijing Tongren Hospital, Children's Hospital Medical Center, Cincinnati, and Beijing Anzhen Hospital.

Browse hlh trials by phase

Treatments under study

About HLH Clinical Trials

Looking for clinical trials for HLH? There are currently 3 studies actively recruiting participants. Clinical trials offer access to new treatments before they are widely available, and every approved therapy in use today was first tested through a clinical trial.

Below you can browse trials, sign up for alerts when new HLH trials open, and view eligibility criteria for each study. Each listing includes the study phase, locations, and enrollment details.

Frequently Asked Questions

Common questions about HLH clinical trials

A clinical trial is a carefully designed research study that tests new medical treatments, drugs, devices, or approaches in human volunteers. Every approved medication and treatment available today was proven safe and effective through clinical trials.

All clinical trials are reviewed and approved by Institutional Review Boards (IRBs) — independent committees that evaluate patient safety. Trials follow strict protocols, and your health is monitored closely throughout. You can withdraw at any time.

Not necessarily. Many trials compare the new treatment against the current standard of care, meaning all participants receive active treatment. When placebos are used, they are typically combined with standard treatment, not given alone. The trial description will always specify the design.

Under the Affordable Care Act, most private insurers are required to cover routine patient care costs during a clinical trial. The sponsor typically covers the investigational treatment itself. Medicare also covers routine costs for qualifying trials.

Yes. Participation is completely voluntary. You can withdraw at any time, for any reason, without it affecting your access to standard medical care.

Each trial has specific eligibility criteria — including age, diagnosis, disease stage, prior treatments, and general health. Browse the trials listed above and check their eligibility sections. You can also contact the trial site directly to discuss your situation.

Showing 18 of 8 trials

Recruiting
Phase 2Phase 3

Open-label Study of ELA026 in Participants With Secondary Hemophagocytic Lymphohistiocytosis (sHLH)

Secondary Hemophagocytic Lymphohistiocytosis (sHLH)
Electra Therapeutics Inc.156 enrolled40 locationsNCT05416307
Recruiting
Phase 1Phase 2

Combination of Mitoxantrone Liposome and Etoposide, Dexamethasone, Pegaspargase and Golidocitinib (MEPL-G) in the Treatment of NK/T-cell Lymphoma Associated Hemophagocytic Lymphohistiocytosis (NKTCL-HLH)

Extranodal NK T Cell LymphomaHemophagocytic Lymphohistiocytosis (HLH)
Beijing Tongren Hospital25 enrolled1 locationNCT07525466
Recruiting
Phase 2

Cord Blood Transplant in Children and Young Adults With Blood Cancers and Non-malignant Disorders

AMLMDSHLH+6 more
Memorial Sloan Kettering Cancer Center31 enrolled1 locationNCT04644016
Recruiting
Early Phase 1

Tadekinig Alfa (IL-18BP) Rescue Therapy for CAR T Cell Related Cytokine Release Syndrome (CRS) and HLH-like Syndrome

CRS - Cytokine Release SyndromeHLH
University of Pennsylvania10 enrolled1 locationNCT05306080
Recruiting
Phase 2

Two-Year Study of the Safety and Efficacy of the Second-Generation Tissue Engineered Vascular Grafts

HLH - Hypoplastic Left Heart SyndromeDORVDILV - Double Inlet Left Ventricle+3 more
Nationwide Children's Hospital24 enrolled1 locationNCT04467671
Recruiting

National Collaborative to Improve Care of Children With Complex Congenital Heart Disease

Hypoplastic Left Heart Syndrome (HLHS)
Children's Hospital Medical Center, Cincinnati1,000 enrolled63 locationsNCT02852031
Recruiting

Prospective Validation of the OHI Index

Hematologic MalignancyHematologic NeoplasmsHLH+2 more
Meir Medical Center300 enrolled2 locationsNCT05882175
Recruiting

An Integrated Prenatal and Postnatal Treatment Model for the Treatment of Newborns With Critical Congenital Heart Disease

Coarctation of AortaCongenital Heart DiseaseAortic Stenosis+9 more
Beijing Anzhen Hospital10,000 enrolled1 locationNCT06768008