Localizing Epileptic Networks Using MRI and iEEG
Optimized Intracranial EEG Targeting in Focal Epilepsy Based Upon Neuroimaging Connectomics
University of Pennsylvania
290 participants
Mar 1, 2021
INTERVENTIONAL
Conditions
Summary
Upon successful completion of this study, the investigators expect the study's contribution to be the development of noninvasive imaging biomarkers to predict IEEG functional dynamics and epilepsy surgical outcomes. Findings from the present study may inform current and new therapies to map and alter seizure spread, and pave the way for less invasive, better- targeted, patient-specific interventions with improved surgical outcomes. This research is relevant to public health because over 20 million people worldwide suffer from focal drug-resistant epilepsy and are potential candidates for cure with epilepsy surgical interventions.
Eligibility
Plain Language Summary
Simplified for easier understanding
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Interventions
Magnetic resonance imaging acquired at a field strength of 3 Tesla.
Epilepsy patients may undergo implantation of intracranial electroencephalography (iEEG) electrodes for localization of epileptogenic foci, which also provide a means to record localized brain activity during memory or other tasks for research purposes.
Magnetic resonance imaging acquired at a field strength of 7 Tesla.
Locations(1)
View Full Details on ClinicalTrials.gov
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NCT04649008