RecruitingNot ApplicableNCT04653064

The Warmth, Anticipation, Sensation, Aversion, and Body-part Imaging Study

Placebo Effects on Anxiety and Pain


Sponsor

Trustees of Dartmouth College

Enrollment

150 participants

Start Date

Mar 19, 2021

Study Type

INTERVENTIONAL

Conditions

Summary

This functional magnetic-resonance imaging study of the brain will feature a within-subject crossover design to investigate the effects of a placebo cream on painful thermal stimulation rendered upon eight body sites. The investigators aim to 1.) improve the understanding of how the brain represents thermal pain responses somatotopically (i.e., across different body-sites) 2.) to test these brain representations with and without the presence of a pain-targeted placebo intervention, and 3.) to examine how these brain representations change prior to vs. during the delivery of thermal pain. They predict that placebo cream will downregulate the intensity of aversive brain activity representations, and to a lesser degree, sensation and somatotopic representations, both prior to and during painful thermal stimulation.


Eligibility

Min Age: 18 Years

Plain Language Summary

Simplified for easier understanding

This is a brain imaging (fMRI) research study that explores how healthy volunteers experience warmth and mild pain sensations. It is not testing a treatment — it is looking at brain activity patterns to better understand pain perception. **You may be eligible if...** - You are a healthy volunteer aged 18 or older - You can read and speak English - You have no current or recent history of chronic pain - You have abstained from alcohol and recreational drugs for 48 hours before the scan - You pass all MRI safety screening checks - If female, you are not pregnant and are using reliable contraception **You may NOT be eligible if...** - You have any metal in your body (implants, pacemaker, shrapnel) or history of working with metal fragments - You are claustrophobic - You have a history of cancer, stroke, seizures, neurological conditions, or cardiovascular disease - You have chronic pain, chronic fatigue, or a history of substance abuse - You have an autoimmune or inflammatory condition - You have a current or recent history of psychiatric illness Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

BEHAVIORALPlacebo Cream

Approximately 1 teaspoon of exfoliating skin scrub delivered approximately 5 minutes prior to pain tasks will coincide with verbal descriptors of the cream as being analgesic.

BEHAVIORALControl Cream

Approximately 1 teaspoon of exfoliating skin scrub delivered approximately 5 minutes prior to pain tasks will coincide with verbal descriptors of the cream as one of no effect.


Locations(1)

Dartmouth College

Hanover, New Hampshire, United States

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NCT04653064


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