Ocular Microbiome and Immune System in Dry Eyes
Associations of the Ocular Microbiome and the Immune System in Dry Eye Disease
Insel Gruppe AG, University Hospital Bern
600 participants
Oct 1, 2020
OBSERVATIONAL
Conditions
Summary
The primary objectives of this study are the characterization of the ocular microbiome as well as of the local immune system in participants with and without dry eye disease. Secondary objectives are the identification of differences in the ocular microbiome as well as in the immune system between participants with and without dry eye disease to ultimately find associations between the ocular microbiome and the immune system in dry eye disease.
Eligibility
Inclusion Criteria2
- Willing to sign informed consent
- years of age or older
Exclusion Criteria5
- Not willing or able to sign informed consent
- Younger than 18 years
- Recent (3 month) history of use of systemic and/or topical antibiotics
- Usage of medical eye drops (Lacrycon and other moisturizing eye drops are allowed)
- Recent (3 month) history of ocular surgery
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Interventions
Taxonomical and functional characterization of the ocular microbiome
Functional characterization of the tear fluid proteome, histology of conjunctival tissue and molecular assays
Locations(1)
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NCT04658238