Dry-Eye Disease Clinical Trials

15 recruitingLast updated: June 20, 2026

There are 15 actively recruiting dry-eye disease clinical trials across 8 countries. Studies span Not Applicable, Phase 2, Early Phase 1, Phase 3. Top locations include Morrow, Georgia, United States, Newport Beach, California, United States, Cranberry Township, Pennsylvania, United States. Updated daily from ClinicalTrials.gov.


Dry-Eye Disease Trials at a Glance

15 actively recruiting trials for dry-eye disease are listed on ClinicalTrialsFinder across 6 cities in 8 countries. The largest study group is Not Applicable with 6 trials, with the heaviest enrollment activity in Morrow, Newport Beach, and Cranberry Township. Lead sponsors running dry-eye disease studies include Beijing Tongren Hospital, TRB Chemedica International SA, and Bausch & Lomb Incorporated.

Browse dry-eye disease trials by phase

Treatments under study

About Dry-Eye Disease Clinical Trials

Looking for clinical trials for Dry-Eye Disease? There are currently 17 studies actively recruiting participants. Clinical trials offer access to new treatments before they are widely available, and every approved therapy in use today was first tested through a clinical trial.

Below you can browse trials, sign up for alerts when new Dry-Eye Disease trials open, and view eligibility criteria for each study. Each listing includes the study phase, locations, and enrollment details.

Frequently Asked Questions

Common questions about Dry-Eye Disease clinical trials

A clinical trial is a carefully designed research study that tests new medical treatments, drugs, devices, or approaches in human volunteers. Every approved medication and treatment available today was proven safe and effective through clinical trials.

All clinical trials are reviewed and approved by Institutional Review Boards (IRBs) — independent committees that evaluate patient safety. Trials follow strict protocols, and your health is monitored closely throughout. You can withdraw at any time.

Not necessarily. Many trials compare the new treatment against the current standard of care, meaning all participants receive active treatment. When placebos are used, they are typically combined with standard treatment, not given alone. The trial description will always specify the design.

Under the Affordable Care Act, most private insurers are required to cover routine patient care costs during a clinical trial. The sponsor typically covers the investigational treatment itself. Medicare also covers routine costs for qualifying trials.

Yes. Participation is completely voluntary. You can withdraw at any time, for any reason, without it affecting your access to standard medical care.

Each trial has specific eligibility criteria — including age, diagnosis, disease stage, prior treatments, and general health. Browse the trials listed above and check their eligibility sections. You can also contact the trial site directly to discuss your situation.

Showing 115 of 15 trials

Recruiting
Not Applicable

Efficacy and Safety of BUFY01 Versus SVS20 in the Treatment of Dry Eye Disease

Dry-Eye Disease
TRB Chemedica International SA80 enrolled2 locationsNCT05865379
Recruiting
Not Applicable

Efficacy and Safety of BUFY02 Versus TRB02 in the Treatment of Dry Eye Disease

Dry-Eye Disease
TRB Chemedica International SA80 enrolled5 locationsNCT05865457
Recruiting
Early Phase 1

Human Umbilical Cord Mesenchymal Stem Cell-derived Small Extracellular Vesicles for the Treatment of Dry Eye Disease

Umbilical Cord Mesenchymal Stem Cell-derived Small Extracellular VesiclesDry-Eye Disease
The First Affiliated Hospital of Xiamen University20 enrolled1 locationNCT07623382
Recruiting
Phase 2

A Study Evaluating the Safety and Efficacy of a Fixed-Dose Combination for Dry Eye Disease

Dry-Eye Disease
Bausch & Lomb Incorporated423 enrolled32 locationsNCT07128628
Recruiting
Phase 3

A Clinical Study to Evaluate the Effect and Side Effect of a New Artificial Tear Formulation (ABBV-444) Compared to Refresh Optive Unit Dose in Adult Participants With Dry Eye Disease

Dry-Eye Disease
AbbVie250 enrolled20 locationsNCT07284381
Recruiting
Not Applicable

An Evaluation of the Safety and Tolerability of Ocular Lubricants

Dry-Eye Disease
Alcon Research148 enrolled4 locationsNCT07238699
Recruiting
Phase 2

Evaluating the Safety, Tolerability, and Efficacy of GRF312 5% in Participants With Dry Eye Disease (DED).

Dry-Eye Disease
Instituto Grifols, S.A.100 enrolled10 locationsNCT07264517
Recruiting

A Study on the Correlation Between Tear Iron Levels and the Severity of Dry Eye Disease.

IronDry-Eye Disease
Shanghai Changzheng Hospital52 enrolled1 locationNCT07363824
Recruiting

2177GCCC:ID'Ing tx Targets and Biomarkers for Ocular Surface Disease in Pt w/ oGVHD

oGVHDDry-Eye Disease
University of Maryland, Baltimore150 enrolled1 locationNCT04946721
Recruiting
Not Applicable

Vit-A-Vision® Clinical Investigation

Burning EyeIrritation; EyeballTired Eye+1 more
OmniVision GmbH77 enrolled1 locationNCT06596733
Recruiting

Ocular Microbiome and Immune System in Dry Eyes

Dry-Eye Disease
Insel Gruppe AG, University Hospital Bern600 enrolled1 locationNCT04658238
Recruiting
Not Applicable

Transcutaneous Auricular Vagus Nerve Stimulation in Dry Eye

Dry-Eye Disease
Beijing Tongren Hospital256 enrolled1 locationNCT06696625
Recruiting
Phase 2

Transcutaneous Auricular Vagus Nerve Stimulation in Dry Eye Disease

Dry-Eye Disease
Beijing Tongren Hospital128 enrolled2 locationsNCT04673643
Recruiting
Not Applicable

Evaluation of the Effectiveness of a Community Health Management Program for Dry Eye Disease in Middle-Aged and Elderly Individuals

Dry-Eye Disease
Fujian University of Traditional Chinese Medicine182 enrolled1 locationNCT06443554
Recruiting

The Pattern of Dry Eye Disease After Cataract Surgery

CataractOcular Surface DiseaseDry-Eye Disease
Lithuanian University of Health Sciences100 enrolled1 locationNCT06298890