Rate or Rhythm Control in CRT: the RHYTHMIC Study

This study is comparing two strategies — controlling heart rate versus controlling heart rhythm — in people with heart failure who have a device called a cardiac resynchronization therapy (CRT) pacemaker. These patients also have atrial fibrillation (an irregular heartbeat) that is reducing how well their pacemaker works. Researchers want to find the best approach to manage this combination of conditions. **You may be eligible if you:** - Have heart failure with a weak left ventricle (pumping chamber) despite being on the best available medications - Have had a CRT pacemaker successfully implanted or upgraded - Have atrial fibrillation that is causing your pacemaker to work less than 95% of the time - Have been recommended by your doctor to have an AV node ablation (a procedure to control heart rate) **You may NOT be eligible if you:** - Have a life expectancy of less than 1 year - Have a blood clot in your heart - Have permanent atrial fibrillation - Have a mechanical heart valve replacement - Have severe peripheral vascular disease (poor circulation in the limbs) - Are pregnant, breastfeeding, or planning pregnancy Talk to your doctor to see if this trial is right for you.