RecruitingNot ApplicableNCT04664946

Intra-arterial Neuroprotective Strategy for Ischemic STroke Patients With No Reperfusion Therapy (INSIST-NRT)

Intra-arterial Neuroprotective Strategy for Ischemic STroke Patients With No Reperfusion Therapy (INSIST-NRT): One Single Center, Safety and Feasibility Study

Sponsor

Hui-Sheng Chen

Enrollment

30 participants

Start Date

Dec 1, 2020

Study Type

INTERVENTIONAL

Conditions

Ischemic Stroke Neuroprotection

Summary

To explore the safety and feasibility of intra-arterial neuroprotective strategy in acute ischemic stroke patients who missed recanalization operation.

Eligibility

Min Age: 18 Years

Inclusion Criteria5

Age ≥18 years;
Major neurologic deficits: 6≤NIHSS≤20;
Missing recanalization therapy (IVT or EVT) or progressive stroke, which was defined as symptoms worsen in 48 hours (an increase in NIHSS more than 4);
Premorbid mRS 0 or 1;
Signed informed consent.

Exclusion Criteria6

Modified Rankin Score >2 caused by a history of prior stroke;
Patients who underwent intravenous thrombolysis or Endovascular treatment;
Coagulation disorders, systematic hemorrhagic tendency, thrombocytopenia （ <80000/mm3;
Severe hepatic or renal dysfunction, increase in ALT or AST (more than 2 times of upper limit of normal value), increase in serum creatinine (more than 1.5 times of upper limit of normal value) or requiring dialysis;
Severe hypertension (systolic blood pressure over 200mmHg or diastolic blood pressure over 110 mmHg);
Unsuitable for this clinical studies assessed by researcher.