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RecruitingNot ApplicableNCT04670640

Mechanistic Interventions and Neuroscience of Dissociation

Sponsor

Emory University

Enrollment

350 participants

Start Date

Sep 18, 2021

Study Type

INTERVENTIONAL

Conditions

Dissociation

Summary

The purpose of this study is to test the neurophysiological mechanisms of an intervention to reduce symptoms of dissociation in traumatized people. The intervention will be tested in dissociative traumatized people at two sites: Emory University and University of Pittsburgh. The researchers are interested in whether neural networks associated with attentional control and interoceptive awareness can be enhanced in this population. The researchers propose to evaluate whether different body-focused and non-body focused interventions can change these mechanisms.

Eligibility

Min Age: 18 YearsMax Age: 65 Years

Plain Language Summary

Simplified for easier understanding

This study is examining the brain science behind dissociation — a mental experience where people feel detached from themselves or their surroundings — in people who have experienced trauma. Researchers want to understand why some trauma survivors develop dissociation and how to treat it more effectively. **You may be eligible if you:** - Have experienced at least one traumatic event (as defined by the DSM-5 criteria) - Have significant dissociation symptoms, particularly depersonalization (feeling detached from yourself), scoring 7 or higher on a standard scale - Are willing to participate in the study **You may NOT be eligible if you:** - Are experiencing active psychosis or have moderate to severe cognitive impairment - Have a moderate or severe substance dependence - Have an imminent risk of violence toward yourself or others Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

DEVICEVibration

Participants will attend two intervention sessions per week for a total of 8 sessions. Participants will sit in a chair in a sound-proof booth monitored by a researcher in front of a computer screen (which delivers instructions) and will be fitted with psychophysiology leads and a device strapped around the chest. There will be no explicit tasks or direction given in this intervention. Participants will experience smooth slowly varying breath-like vibration on their sternum. They will receive their assigned intervention for approximately 18 minutes.

BEHAVIORALBreath Focus

Participants will attend two intervention sessions per week for a total of 8 sessions. Participants will sit in a chair in a sound-proof booth monitored by a researcher in front of a computer screen (which delivers instructions) and will be fitted with psychophysiology leads and a device strapped around the chest. The participant will be asked to focus on their breathing during this intervention. They will receive their assigned intervention for approximately 18 minutes.

BEHAVIORALNo Distractions

Participants will attend two intervention sessions per week for a total of 8 sessions. Participants will sit in a chair in a sound-proof booth monitored by a researcher in front of a computer screen (which delivers instructions) and will be fitted with psychophysiology leads and a device strapped around the chest. Participants will engage in a period of no-screen time; during this time there will be no outside visual or auditory distractions. There will be no explicit tasks or direction given in this intervention. They will receive their assigned intervention for approximately 18 minutes.

Locations(2)

Grady Hospital

Atlanta, Georgia, United States

Western Psychiatric Institute and Clinic

Pittsburgh, Pennsylvania, United States

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NCT04670640

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