RecruitingNot ApplicableNCT04676828

Functional Lung Avoidance SPECT-guided Radiation Therapy of Lung Cancer

Functional Lung Avoidance SPECT-guided (ASPECT) Radiation Therapy for Lung Cancer Patients: Phase II Randomised Clinical Trial


Sponsor

University of Aarhus

Enrollment

90 participants

Start Date

Dec 1, 2021

Study Type

INTERVENTIONAL

Conditions

Summary

Study aims to determine if functional lung avoidance based on perfusion single photon emission (SPECT)/CT scan, improves toxicity outcomes for patients with advanced lung cancer undergoing chemo-radiotherapy. Functional avoidance implies a dose plan that takes functional distribution in the lung into account, and avoids highly functional lung volumes sparing them from radiation.


Eligibility

Min Age: 18 Years

Plain Language Summary

Simplified for easier understanding

This study is testing a radiation therapy technique called Functional Lung Avoidance, which uses special imaging (SPECT scans) to map which parts of the lung are actively working and then designs radiation treatment to spare those healthy, functioning areas. This approach aims to reduce lung damage and breathing problems caused by radiation in patients with lung cancer. **You may be eligible if you:** - Have been diagnosed with lung cancer (small-cell or non-small cell) - Are receiving radiation therapy with the goal of curing the cancer (curative intent) - Are 18 years of age or older - Have given informed consent **You may NOT be eligible if you:** - Are receiving concurrent immunotherapy alongside your radiation - Have had previous radiation treatment to the chest Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

DIAGNOSTIC_TESTSingle-photon-emission CT scan

SPECT/CT scan is an established functional modality used in the diagnosis and monitoring of lung disease. SPECT/CT scan images pulmonary circulation, where perfused areas equate with normal functional lung


Locations(2)

Sydney West Radiation Oncology Network Westmead and Blacktown Hospitals

Sydney, New South Wales, Australia

Department of Oncology, Aarhus University Hospital

Aarhus, Denmark

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NCT04676828


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