RecruitingNot ApplicableNCT04677244

Echo-endoscopy Biopsy Impact on the Circulating Tumor Cell Level

Impact of Echo-endoscopy Biopsy on the Circulating Tumor Cell Level in the Portal System in Pancreatic Adenocarcinoma Management Care

Sponsor

Institut Paoli-Calmettes

Enrollment

42 participants

Start Date

Nov 11, 2021

Study Type

INTERVENTIONAL

Conditions

Cancer of Pancreas

Summary

The aim of this work is to evaluate the impact of endoscopic procedures on the circulating tumoral cells level in order to evaluate the potential effects of an endoscopic procedure in the management of pancreatic tumors.

Eligibility

Min Age: 40 YearsMax Age: 85 Years

Plain Language Summary

Simplified for easier understanding

This study is investigating whether performing a biopsy of a suspected pancreatic tumor using an endoscopic ultrasound (a camera inserted via the throat) affects the number of circulating tumor cells — cancer cells that have broken off the tumor and are traveling in the bloodstream. Researchers want to understand if this procedure increases the risk of cancer cells spreading. **You may be eligible if you:** - Are between 40 and 85 years old - Have a BMI under 30 kg/m² - Are suspected of having pancreatic cancer and are scheduled for an endoscopic ultrasound biopsy and/or biliary drainage procedure - Are affiliated with a social security scheme **You may NOT be eligible if you:** - Are pregnant, likely to become pregnant, or breastfeeding - Are unable to give consent or are under a legal protection measure - Have had a prior biliary drainage attempt outside of the study center - Have had previous treatment for the pancreatic condition being studied Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

PROCEDUREBlood sample in portal vein

A 6 ml blood sample will be taken from the portal vein, before and after the echo-endoscopic biopsy of the pancreatic mass. The second sample will be taken after the biopsy if there is no bile drainage, or after bile drainage if indicated. The delay between the end of the biopsy procedure and the puncture will be 5 minutes. A 6 ml peripheral blood sample will also be taken before and after the endoscopic procedure.