A Personalized Surveillance and Intervention Protocol for Duodenal and Gastric Polyposis in Patients With Familial Adenomatous Polyposis

This study is creating a personalized monitoring and treatment protocol for patients with Familial Adenomatous Polyposis (FAP) — a hereditary condition causing many polyps (pre-cancerous growths) throughout the digestive system, including the stomach and small intestine (duodenum). Researchers want to improve how these at-risk patients are watched over time to prevent cancer from developing. **You may be eligible if you:** - Have been diagnosed with FAP, confirmed either by genetic testing (APC gene mutation) or by clinical diagnosis (100+ colorectal polyps with a family history of FAP) - Are 18 years of age or older - Have not yet developed stomach or duodenal (small intestine) cancer - Do not require surgery at this time **You may NOT be eligible if you:** - Have cancer detected in your stomach or small intestine at baseline endoscopy - Cannot have all polyps removed endoscopically - Require surgery now Talk to your doctor to see if this trial is right for you.