RecruitingNCT04677998

A Personalized Surveillance and Intervention Protocol for Duodenal and Gastric Polyposis in Patients With Familial Adenomatous Polyposis

Sponsor

Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)

Enrollment

1,000 participants

Start Date

Nov 24, 2020

Study Type

OBSERVATIONAL

Conditions

Familial Adenomatous Polyposis

Summary

The purpose of this study is to determine the efficacy and safety of a personalized surveillance and intervention protocol for duodenal and gastric polyposis in patients with familial adenomatous polyposis (FAP)

Eligibility

Min Age: 18 Years

Inclusion Criteria2

Diagnosis of FAP, at least one of following: genetic diagnosis (proven APC germline mutation) and/or clinical diagnosis (\>100 colorectal adenomas in combination with a positive family history of FAP)
Age 18 years or older

Exclusion Criteria3

Endoscopic removal of all polyps with an indication for removal not possible/feasible
Gastric or duodenal cancer at baseline endoscopy
Need for surgery

Interventions

PROCEDUREPersonalized surveillance and intervention protocol

This study uses one arm. Participants will undergo endoscopic surveillance with intervals between 3-6 months and 5 years, depending on severity of polyposis and performed endoscopic interventions.

Locations(2)

MD Anderson

Houston, Texas, United States

Academic Medical Centre

Amsterdam, North Holland, Netherlands

View Full Details on ClinicalTrials.gov

For the most up-to-date information, visit the official listing.

Visit

NCT04677998

Related Trials

Testing for Safety and Colorectal Cancer Preventive Effects of ONC201

NCT056307945 locations

A Personalized Surveillance and Intervention Protocol for Patients With Familial Adenomatous Polyposis That Have Undergone (Procto)Colectomy

NCT046780112 locations